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Clinitians' Biosecurity Network
  
Emergency Resources

 

This Website is supported by funding from the Alfred P. Sloan Foundation.

CBN Report Archive 

Organized by Topic | by Date

This archive lists CBN Reports published within the past 18 months, organized by topic.

Agents and Diseases

CBN Agents and Diseases

Clinicians' Biosecurity Network Report archive for biosecurity agents and diseases.

  1. Adenovirus 14: An Emerging Threat (04-17-2009)

    The Journal of Infectious Disease has just published 2 papers by teams of researchers describing separate, severe outbreaks of Adenovirus 14 (Ad14), a historically rare serotype of adenovirus that has not been known to cause severe disease.
    Fri, 17 Apr 2009 14:42:36 GMThttp://www.upmc-cbn.org/report_archive/2009/04_April_2009/cbnreport_04172009.html

  2. 3rd Generation Smallpox Vaccine LC16m8 Proved Safe and Immunogenic (03-20-2009)

    New JAMA study from Japanese researchers testing LC16m8, tissue-cultured 3rd gen smallpox vaccine. Overall, the vaccine displayed high levels of vaccine take in primary vaccinees and provoked an effective booster response in some revaccinees.
    Fri, 20 Mar 2009 13:31:31 GMThttp://www.upmc-cbn.org/report_archive/2009/03_March_2009/cbnreport_03202009.html

  3. Longer Treatment Window for Botulism (02-20-2009)

    Results from a new study published in JID demonstrate the persistence of botulinum toxin in the serum of patients up to 11 days after exposure. The prolonged persistence of toxin allows for admin of anti-toxin as long 12 days after toxin ingestion
    Fri, 20 Feb 2009 17:53:50 GMThttp://www.upmc-cbn.org/report_archive/2009/02_February_2009/cbnreport_02202009.html

  4. Update on Smallpox Vaccine (01-08-2009)

    The 2001 anthrax attacks spurred new vaccine development, and, as a result, there have been several updates to the smallpox vaccine armamentarium, which are reviewed here.
    Fri, 09 Jan 2009 13:42:32 GMThttp://www.upmc-cbn.org/report_archive/2009/01_January_2009/cbnreport_01092009.html

  5. Long-lived Immunity after Smallpox Vaccination (12-05-2008)

    Researchers from NIA have just reported results of a study in which 97% of 209 vaccinated subjects maintained antibody titers for up to 88 years. While promising, these results must be interpreted carefully.
    Fri, 05 Dec 2008 14:05:41 GMThttp://www.upmc-cbn.org/report_archive/2008/12_December_2008/cbnreport_12052008.html

  6. New Arenavirus Identified as Cause of Cluster of Illness and Death in South Africa and Zambia (11-07-2008)

    Through molecular diagnostic techniques, a previously unknown arenavirus has been identified as the etiologic agent responsible for 4 deaths in Africa that occurred in September and October of 2008.
    Fri, 07 Nov 2008 20:12:16 GMThttp://www.upmc-cbn.org/report_archive/2008/11_November_2008/cbnreport_11072008.html

  7. Atypical Presentation of Cutaneous Tularemia (06-27-2008)

    Summary of article from 7-01-2008 issue of CID: Byington and colleagues describe cutaneous tularemia in two children who were initially misdiagnosed due to atypical presentations of the disease.
    Fri, 27 Jun 2008 19:53:59 GMThttp://www.upmc-cbn.org/report_archive/2008/06_June_2008/cbnreport_06272008

  8. CDC Publishes Report on Meeting of Experts to Update Guidelines for Management of Anthrax (04-14-2008)

    2008: CDC convened subjects matter experts to review and update guidelines for anthrax TX and make consensus recommendations for updating guidelines for PEP, TX, and clinical eval of patients. Read summary of EID's report.
    Mon, 14 Apr 2008 19:36:17 GMThttp://www.upmc-cbn.org/report_archive/2008/04_April_2008/cbnreport_04142008.html

  9. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 21:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  10. HHS Award Multiple Contracts for Anthrax Countermeasures (09-28-2007)

    CBN Report: BARDA awarded contracts for advanced development of anthrax countermeasures Anthim and Valortim. BARDA also awarded a purchase contract for BioThrax anthrax vaccine.
    Mon, 01 Oct 2007 13:32:31 GMThttp://www.upmc-cbn.org/report_archive/2007/09_September_2007/cbnreport_09282007.html

  11. The Potential Disaster of Extensively Drug Resistant Tuberculosis (11-10-2006)

    At the recent meeting of the IDSA in Toronto (October 12-15, 2006), Dr. Henry Blumberg of the Emory University School of Medicine presented a comprehensive review of tuberculosis in the world. The picture is grim.
    Fri, 10 Nov 2006 14:43:00 GMThttp://www.upmc-cbn.org/report_archive/2006/11_November_2006/cbnreport_111006.html

  12. Smallpox Antiviral Effective in Animal Trials (10-23-2006)

    On October 18, 2006, SIGA Technologies, Inc. announced that its antiviral drug candidate SIGA-246 demonstrated a high degree of protection against variola, the smallpox virus, in a primate trial conducted at the CDC.
    Mon, 23 Oct 2006 20:15:00 GMThttp://www.upmc-cbn.org/report_archive/2006/10_October_2006/cbnreport_102306.html

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Avian/Pandemic Influenza

CBN Avian-Pandemic Flu

Clinicians' Biosecurity Network Report archive for avian, pandemic flu.

  1. H7-subtype Influenza Infections: Pandemic Potential? (06-05-2009)

    However, the pandemic potential of the H7 viruses cannot be overlooked. While they are not nearly as lethal as H5N1, a pandemic need not cause mass lethality to have a significant impact around the globe.
    Fri, 05 Jun 2009 17:48:59 GMThttp://www.upmc-cbn.org/report_archive/2009/06_June_2009/cbnreport_06052009.html

  2. 04-24-2009: Swine Flu Cases Without Swine Exposure

    On 4/21/2009, the CDC described 2 cases of swine flu A (H1N1) infection in Southern CA in April. While both patients recovered uneventfully, the isolated viruses harbor novel genetic characteristics not seen in the U.S. prior to this event.
    Fri, 24 Apr 2009 13:26:22 GMThttp://www.upmc-cbn.org/report_archive/2009/h1n1/04-09_Swine_Flu/cbnreport_SF1_4-24-09_AM.html

  3. Oseltamivir Protective Against Influenza-induced Cardiac Events (04-03-2009)

    A new study finds that antiviral therapy can reduce cardiovascular complications following influenza infection in patients with previous cardiac disease.
    Thu, 02 Apr 2009 21:41:56 GMThttp://www.upmc-cbn.org/report_archive/2009/04_April_2009/cbnreport_04032009

  4. Broad-spectrum Flu Antibodies Characterized (03-06-2009)

    Two teams of researchers recently and simultaneously reported discovery and development of antibodies generated against invariate regions of the influenza virus.
    Fri, 06 Mar 2009 19:10:52 GMThttp://www.upmc-cbn.org/report_archive/2009/03_March_2009/cbnreport_03062009

  5. Global Avian influenza Panzootic Continues; Some Preparedness Gains Made but Hospitals Remain Vulnerable (02-06-2009)

    Although "bird flu" has not been featured prominently on the evening news of late, the influenza A/H5N1 panzootic continues. And, as has been true since this global outbreak erupted in Thailand and Vietnam, it remains distinctly seasonal in nature.
    Fri, 06 Feb 2009 19:13:05 GMThttp://www.upmc-cbn.org/report_archive/2009/02_February_2009/cbnreport_02062009.html

  6. Is Airborne Spread of Influenza Possible? (01-22-2009)

    A new study demonstrates that the flu virus is able to remain suspended in the air, thus enabling airborne transmission. This finding suggests the possible need for more stringent infection control measures to forestall spread of flu in hospitals.
    Thu, 22 Jan 2009 20:10:34 GMThttp://www.upmc-cbn.org/report_archive/2009/01_January_2009/cbnreport_01222009.html

  7. Update on Personal Protective Equipment (12-19-2008)

    Two recent studies raise questions about best use of PPE and assumptions underlying related current recommendations.
    Fri, 19 Dec 2008 20:43:12 GMThttp://www.upmc-cbn.org/report_archive/2008/12_December_2008/cbnreport_12192008.html

  8. Modeling Drug Resistant Influenza (11-21-2008)

    In a new mathematical modeling study Brockmann and colleagues report that drug resistant influenza was capable of increasing hospitalization rates by up to 233% in a hypothetical Swiss town of 100,000 inhabitants.
    Mon, 24 Nov 2008 15:44:28 GMThttp://www.upmc-cbn.org/report_archive/2008/11_November_2008/cbnreport_11212008.html

  9. Rising Staphylococcus aureus Co-infection among Pediatric Influenza Deaths (10-10-2008)

    The results of a study of pediatric flu mortality for 3 flu seasons, by CDC investigators, were published recently. The authors report an increase in the incidence of bacterial co-infection in fatal pediatric flu from 6 to 34 percent in that period.
    Fri, 10 Oct 2008 15:08:11 GMThttp://www.upmc-cbn.org/report_archive/2008/10_October_2008/cbnreport_10092008.html

  10. Hong Kong Study Finds that Closing Schools May Not Have Helped Slow the Spread of Flu (09-26-2008)

    A new study published in Emerging Infectious Diseases (EID) suggests that Hong Kong�s efforts to close schools for two weeks during the 2008 influenza season may have done little to limit the community-wide spread of influenza.
    Fri, 26 Sep 2008 19:21:39 GMThttp://www.upmc-cbn.org/report_archive/2008/09_September_2008/cbnreport_09262008.html

  11. The Role of Bacterial Pneumonia in Pandemic Influenza (09-12-2008)

    A paper by researchers from NIAID concludes that most deaths during the 1918 flu pandemic appear to have involved bacterial pneumonia rather than purely viral pneumonia. This has important implications for pandemic flu planning now.
    Fri, 12 Sep 2008 20:58:00 GMThttp://www.upmc-cbn.org/report_archive/2008/09_September_2008/cbnreport_09122008.html

  12. Utility of Antivirals During a Pandemic: Uncertainties Persist (07-30-2008)

    During a pandemic, neuraminidase inhibitors will be the antivirals of choice. But there remains uncertainty about their usefulness because access may be limited, resistance may develop, the dose and duration of treatment is uncertain, etc.
    Wed, 30 Jul 2008 14:39:20 GMThttp://www.upmc-cbn.org/report_archive/2008/07_July_2008/cbnreport_07302008.html

  13. AHRQ Releases Report on Home Healthcare During a Pandemic (07-14-2008)

    CBN Report: On July 8, 2008, the Department of Health and Human Services (HHS) Agency for Healthcare, Research and Quality (AHRQ) released a report on the issues and resources associated with home healthcare during a pandemic.
    Mon, 14 Jul 2008 18:22:10 GMThttp://www.upmc-cbn.org/report_archive/2008/07_July_2008/cbnreport_07142008.html

  14. Evolution of H7 Avian Influenza: Another Pandemic Candidate? (06-06-2008)

    Belser and colleagues report results of study results indicating that some recent strains of avian influenza virus have developed ability to bind to receptors in the human respiratory tract and to spread efficiently between ferrets.
    Fri, 06 Jun 2008 20:26:17 GMThttp://www.upmc-cbn.org/report_archive/2008/06_June_2008/cbnreport_06062008

  15. OSHA Issues Guidance for Stockpiling Masks and Respirators (05-30-2008)

    OSHA's has proposed new guidelines for determining types, numbers, and costs of masks and respirators to stockpile for use during an influenza pandemic to protect healthcare workers. Guidelines are non-obligatory, but useful planning tool.
    Mon, 02 Jun 2008 20:20:08 GMThttp://www.upmc-cbn.org/report_archive/2008/05_May_2008/cbnreport_05302008.html

  16. Indonesia Conducts 3-Day Drill of Pandemic Influenza National Response Plan (05-01-2008)

    Indonesia holds large scale pandemic influenza drill, April 25 - April 27, 2008.
    Thu, 01 May 2008 19:58:31 GMThttp://www.upmc-cbn.org/report_archive/2008/05_May_2008/cbnreport_05012008.html

  17. This Year's flu Season Marked by Vaccine Mismatch in the U.S. and Antiviral Resistance in Europe (02-14-2008)

    CDC reports that this year's flu season in U.S. is more severe than past 2 and that vaccine does not match 43% of strains circulating in U.S. In Europe, there are reports of unexplained oseltamivir resistance.
    Thu, 14 Feb 2008 20:55:53 GMThttp://www.upmc-cbn.org/report_archive/2008/02_February_2008/cbnreport_02142008.html

  18. Progress Toward the Development of a Universal Influenza Vaccine (02-01-2008)

    Acambis , a vaccine development company, announced positive preliminary results from two studies of its universal influenza vaccine, ACAM-FLU-A
    Fri, 01 Feb 2008 15:26:45 GMThttp://www.upmc-cbn.org/report_archive/2008/02_February_2008/cbnreport_02012008.html

  19. WHO Update on Human H5N1 Infections (01-18-2008)

    WHO Committee Human Infection with Avian Influenza A (H5N1) Virus provides updated information on human cases of highly pathogenic avian influenza A (H5N1) infection.
    Tue, 22 Jan 2008 15:00:49 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01182008

  20. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 17:47:46 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  21. Evidence for a Heritable Predisposition to Fatal Influenza (12-19-2007)

    CBN Report: A recent study by Albright and colleagues from the University of Utah School of Medicine supports the hypothesis that there exists an inherited predisposition to developing and dying from severe influenza.
    Wed, 19 Dec 2007 18:39:00 GMThttp://www.upmc-cbn.org/report_archive/2007/12_December_2007/cbnreport_12192007.html

  22. Estimate of the Financial Effect of a Flu Pandemic on U.S. Hospitals (12-07-2007)

    CBN Report: Center for Biosecurity estimates potential financial impact of a flu pandemic on U.S. hospitals to be approximately $785,000 for average U.S. hospital, and $3.9 billion total for all U.S. hospitals.
    Fri, 07 Dec 2007 18:37:25 GMThttp://www.upmc-cbn.org/report_archive/2007/12_December_2007/cbnreport_12072007

  23. Recent H5N1 Developments (10-15-2007)

    CBN Report: Recent articles shed light on the virulence and pathogenesis of H5N1 and suggest a possible new approach to treatment.
    Mon, 15 Oct 2007 15:21:54 GMThttp://www.upmc-cbn.org/report_archive/2007/10_October_2007/cbnreport_10152007.html

  24. IOM Releases Pandemic PPE Report (10-04-2007)

    CBN Report: IOM released a report entitled, "Preparing for an Influenza Pandemic: PPE for Healthcare Workers" stating that the regulatory, certification, and evaluation requirements for PPE need to be revisited to ensure PPE are safe and effective.
    Thu, 04 Oct 2007 20:00:05 GMThttp://www.upmc-cbn.org/report_archive/2007/10_October_2007/cbnreport_10042007.html

  25. Passive Immunization with Human Monoclonal Antibodies in H5N1 (05-30-2007)

    CBN Report: Passive immunotherapy with neutralizing H5N1 human monoclonal antibodies (mAbs) is effective in preventing and treating H5N1 infection in a murine model.
    Wed, 30 May 2007 16:03:23 GMThttp://www.upmc-cbn.org/report_archive/2007/05_May_2007/cbnreport_05302007.html

  26. OSHA Releases Pandemic Guidance for Healthcare Personnel (05-24-2007)

    CBN Report: OSHA released Pandemic Influenza Preparedness and Response Guidance for Healthcare Workers and Healthcare Employers which provides a concise yet comprehensive overview of the occupational health issues related to hospital pandemic prep.
    Thu, 24 May 2007 15:17:19 GMThttp://www.upmc-cbn.org/report_archive/2007/05_May_2007/cbnreport_05242007.html

  27. Seasonal Flu Vaccination May Offer Partial Immunity to H5N1 (02-21-2007)

    mice vaccinated with the N1 used in seasonal flu vaccine, had significantly reduced mortality when challenged with H5N1. Some people who have had seasonal influenza vaccination carry antibodies that react to the N1 in the avian H5N1 virus
    Wed, 21 Feb 2007 19:58:37 GMThttp://www.upmc-cbn.org/report_archive/2007/02_February_2007/cbnreport_02212007.html

  28. CDC Releases Interim Planning Guidance for Mitigation of Pandemic Influenza (02-07-2007):

    CBN Report: The CDC released its disease containment strategy for pandemic flu: Interim Pre-pandemic Planning Guidance: Community Strategy for pandemic Influenza Mitigation in the United States.
    Wed, 07 Feb 2007 19:34:48 GMThttp://www.upmc-cbn.org/report_archive/2007/02_February_2007/cbnreport_02072007.html

  29. Influenza Update: Diagnostic Test, Drug Resistance, and Possible Drug Interaction (11-16-2006)

    Researchers at the University of Colorado, the CDC, and InDevR, LLC have designed a gene chip assay that can identify and subtype Influenza A virus, distinguishing, for example, between H3N2 and H5N1 in less than 7 hours.
    Thu, 16 Nov 2006 20:22:00 GMThttp://www.upmc-cbn.org/report_archive/2006/11_November_2006/cbnreport_111606.html

  30. Smallpox Antiviral Effective in Animal Trials (10-23-2006)

    On October 18, 2006, SIGA Technologies, Inc. announced that its antiviral drug candidate SIGA-246 demonstrated a high degree of protection against variola, the smallpox virus, in a primate trial conducted at the CDC.
    Mon, 23 Oct 2006 18:45:00 GMThttp://www.upmc-cbn.org/report_archive/2006/10_October_2006/cbnreport_102306.html

  31. Predicting the Impact of a Flu Epidemic (12-01-2005)

    On November 7, 2005 the CDC released a new version of its FluSurge program which . . . calculates the impact on hospital capacity over the course of an epidemic . . .
    Thu, 01 Dec 2005 20:15:00 GMThttp://www.upmc-cbn.org/report_archive/2005/12_December_2005/cbnreport_120105.html

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Countermeasure Development

CBN Countermeasure Developments

Clinicians' Biosecurity Network Report archive for countermeasure development.

  1. 3rd Generation Smallpox Vaccine LC16m8 Proved Safe and Immunogenic (03-20-2009)

    New JAMA study from Japanese researchers testing LC16m8, tissue-cultured 3rd gen smallpox vaccine. Overall, the vaccine displayed high levels of vaccine take in primary vaccinees and provoked an effective booster response in some revaccinees.
    Fri, 20 Mar 2009 13:31:31 GMThttp://www.upmc-cbn.org/report_archive/2009/03_March_2009/cbnreport_03202009.html

  2. Update on Smallpox Vaccine (01-08-2009)

    The 2001 anthrax attacks spurred new vaccine development, and, as a result, there have been several updates to the smallpox vaccine armamentarium, which are reviewed here.
    Fri, 09 Jan 2009 13:42:32 GMThttp://www.upmc-cbn.org/report_archive/2009/01_January_2009/cbnreport_01092009.html

  3. Long-lived Immunity after Smallpox Vaccination (12-05-2008)

    Researchers from NIA have just reported results of a study in which 97% of 209 vaccinated subjects maintained antibody titers for up to 88 years. While promising, these results must be interpreted carefully.
    Fri, 05 Dec 2008 14:05:41 GMThttp://www.upmc-cbn.org/report_archive/2008/12_December_2008/cbnreport_12052008.html

  4. Progress Toward the Development of a Universal Influenza Vaccine (02-01-2008)

    Acambis , a vaccine development company, announced positive preliminary results from two studies of its universal influenza vaccine, ACAM-FLU-A
    Fri, 01 Feb 2008 15:26:45 GMThttp://www.upmc-cbn.org/report_archive/2008/02_February_2008/cbnreport_02012008.html

  5. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 21:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  6. Smallpox Antiviral Effective in Animal Trials (10-23-2006)

    On October 18, 2006, SIGA Technologies, Inc. announced that its antiviral drug candidate SIGA-246 demonstrated a high degree of protection against variola, the smallpox virus, in a primate trial conducted at the CDC.
    Mon, 23 Oct 2006 20:15:00 GMThttp://www.upmc-cbn.org/report_archive/2006/10_October_2006/cbnreport_102306.html

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Government Policy and Programs

CBN Government Policy and Programs

Clinicians' Biosecurity Network Report archive for government policy and programs.

  1. Utility of Antivirals During a Pandemic: Uncertainties Persist (07-30-2008)

    During a pandemic, neuraminidase inhibitors will be the antivirals of choice. But there remains uncertainty about their usefulness because access may be limited, resistance may develop, the dose and duration of treatment is uncertain, etc.
    Wed, 30 Jul 2008 14:39:20 GMThttp://www.upmc-cbn.org/report_archive/2008/07_July_2008/cbnreport_07302008.html

  2. ASPR Makes First Playbook Available (03-28-2008)

    DHHS/ASPR has published the first in a planned series of playbooks addressing response to disasters and other large scale emergencies.
    Fri, 28 Mar 2008 19:15:00 GMThttp://www.upmc-cbn.org/report_archive/2008/03_March_2008/cbnreport_03282008.html

  3. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 21:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  4. National Academies Report on Boston BSL-4 Laboratory (11-30-2007)

    Yesterday, a National Research Council (NRC) committee deemed an NIH risk analysis for a proposed biocontainment laboratory at Boston University to be "not sound and credible."
    Fri, 30 Nov 2007 20:54:00 GMThttp://www.upmc-cbn.org/report_archive/2007/11_November_2007/cbnreport_11302007.html

  5. CDC Releases Interim Planning Guidance for Mitigation of Pandemic Influenza (02-07-2007):

    CBN Report: The CDC released its disease containment strategy for pandemic flu: Interim Pre-pandemic Planning Guidance: Community Strategy for pandemic Influenza Mitigation in the United States.
    Wed, 07 Feb 2007 19:34:49 GMThttp://www.upmc-cbn.org/report_archive/2007/02_February_2007/cbnreport_02072007.html

  6. Passage of S. 3678-The Pandemic and All-Hazards Preparedness Act (12-20-2006)

    Summary of the details of the passage of S. 3678: The Pandemic and All-Hazards Preparedness Act.
    Wed, 20 Dec 2006 15:05:00 GMThttp://www.upmc-cbn.org/report_archive/2006/12_December_2006/cbnreport_122006.html

  7. 500,000 Doses of Attenuated Smallpox Vaccine Delivered to U.S. Government (12-07-2005)

    In September 2004, Acambis was awarded a contract by the NIAID to develop and manufacture a modified Vaccinia Ankara (MVA) smallpox vaccine.
    Wed, 07 Dec 2005 20:14:00 GMThttp://www.upmc-cbn.org/report_archive/2005/12_December_2005/cbnreport_120705.html

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Guidelines and Recommendations

CBN Guidelines and Recommendations

Clinicians' Biosecurity Network Report archive for guidelines and recommendations.

  1. OSHA Issues Guidance for Stockpiling Masks and Respirators (05-30-2008)

    OSHA's has proposed new guidelines for determining types, numbers, and costs of masks and respirators to stockpile for use during an influenza pandemic to protect healthcare workers. Guidelines are non-obligatory, but useful planning tool.
    Mon, 02 Jun 2008 20:20:08 GMThttp://www.upmc-cbn.org/report_archive/2008/05_May_2008/cbnreport_05302008.html

  2. Definitive Care for the Critically Ill During a Disaster: Report of the Task Force for Mass Critical Care of the American College of Chest Physicians Released (05-15-2008)

    Reviews preparedness for mass critical care; suggests an alternative approach to provide only essential critical care; specifies types of equipment, staffing, and space required; and suggests a framework for allocation of scarce critical care resources.
    Thu, 15 May 2008 16:18:30 GMThttp://www.upmc-cbn.org/report_archive/2008/05_May_2008/cbnreport_05152008.html

  3. CDC Publishes Report on Meeting of Experts to Update Guidelines for Management of Anthrax (04-14-2008)

    2008: CDC convened subjects matter experts to review and update guidelines for anthrax TX and make consensus recommendations for updating guidelines for PEP, TX, and clinical eval of patients. Read summary of EID's report.
    Mon, 14 Apr 2008 19:36:17 GMThttp://www.upmc-cbn.org/report_archive/2008/04_April_2008/cbnreport_04142008.html

  4. California Releases Healthcare Surge Guidelines (02-29-2008)

    On February 19, 2008, the California Department of Public Health released its Standards and Guidelines for Healthcare Surge during Emergencies.
    Fri, 29 Feb 2008 20:37:23 GMThttp://www.upmc-cbn.org/report_archive/2008/02_February_2008/cbnreport_022908.html

  5. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 21:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  6. CDC Releases Interim Planning Guidance for Mitigation of Pandemic Influenza (02-07-2007):

    CBN Report: The CDC released its disease containment strategy for pandemic flu: Interim Pre-pandemic Planning Guidance: Community Strategy for pandemic Influenza Mitigation in the United States.
    Wed, 07 Feb 2007 19:34:50 GMThttp://www.upmc-cbn.org/report_archive/2007/02_February_2007/cbnreport_02072007.html

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Hospital Preparedness

CBN Hospital Preparedness

Clinicians' Biosecurity Network Report archive for hospital preparedness.

  1. Hospitals Are Better Prepared for Mass Casualty Disasters (05-08-2009)

    Based on interviews with 133 individuals involved with disaster preparedness in hospitals across the U.S., we found that hospitals are significantly better prepared now than in 2001; much of the improvement is attributable to the HPP.
    Fri, 08 May 2009 15:36:45 GMThttp://www.upmc-cbn.org/report_archive/2009/05_May_2009/cbnreport_05082009.html

  2. Global Avian influenza Panzootic Continues; Some Preparedness Gains Made but Hospitals Remain Vulnerable (02-06-2009)

    Although "bird flu" has not been featured prominently on the evening news of late, the influenza A/H5N1 panzootic continues. And, as has been true since this global outbreak erupted in Thailand and Vietnam, it remains distinctly seasonal in nature.
    Fri, 06 Feb 2009 19:13:05 GMThttp://www.upmc-cbn.org/report_archive/2009/02_February_2009/cbnreport_02062009.html

  3. Is Airborne Spread of Influenza Possible? (01-22-2009)

    A new study demonstrates that the flu virus is able to remain suspended in the air, thus enabling airborne transmission. This finding suggests the possible need for more stringent infection control measures to forestall spread of flu in hospitals.
    Thu, 22 Jan 2009 20:10:34 GMThttp://www.upmc-cbn.org/report_archive/2009/01_January_2009/cbnreport_01222009.html

  4. Update on Personal Protective Equipment (12-19-2008)

    Two recent studies raise questions about best use of PPE and assumptions underlying related current recommendations.
    Fri, 19 Dec 2008 20:43:12 GMThttp://www.upmc-cbn.org/report_archive/2008/12_December_2008/cbnreport_12192008.html

  5. OSHA Issues Guidance for Stockpiling Masks and Respirators (05-30-2008)

    OSHA's has proposed new guidelines for determining types, numbers, and costs of masks and respirators to stockpile for use during an influenza pandemic to protect healthcare workers. Guidelines are non-obligatory, but useful planning tool.
    Mon, 02 Jun 2008 20:20:08 GMThttp://www.upmc-cbn.org/report_archive/2008/05_May_2008/cbnreport_05302008.html

  6. Definitive Care for the Critically Ill During a Disaster: Report of the Task Force for Mass Critical Care of the American College of Chest Physicians Released (05-15-2008)

    Reviews preparedness for mass critical care; suggests an alternative approach to provide only essential critical care; specifies types of equipment, staffing, and space required; and suggests a framework for allocation of scarce critical care resources.
    Thu, 15 May 2008 16:18:30 GMThttp://www.upmc-cbn.org/report_archive/2008/05_May_2008/cbnreport_05152008.html

  7. California Releases Healthcare Surge Guidelines (02-29-2008)

    On February 19, 2008, the California Department of Public Health released its Standards and Guidelines for Healthcare Surge during Emergencies.
    Fri, 29 Feb 2008 20:37:23 GMThttp://www.upmc-cbn.org/report_archive/2008/02_February_2008/cbnreport_022908.html

  8. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 21:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  9. Estimate of the Financial Effect of a Flu Pandemic on U.S. Hospitals (12-07-2007)

    CBN Report: Center for Biosecurity estimates potential financial impact of a flu pandemic on U.S. hospitals to be approximately $785,000 for average U.S. hospital, and $3.9 billion total for all U.S. hospitals.
    Fri, 07 Dec 2007 18:37:25 GMThttp://www.upmc-cbn.org/report_archive/2007/12_December_2007/cbnreport_12072007

  10. IOM Releases Pandemic PPE Report (10-04-2007)

    CBN Report: IOM released a report entitled, "Preparing for an Influenza Pandemic: PPE for Healthcare Workers" stating that the regulatory, certification, and evaluation requirements for PPE need to be revisited to ensure PPE are safe and effective.
    Thu, 04 Oct 2007 20:00:05 GMThttp://www.upmc-cbn.org/report_archive/2007/10_October_2007/cbnreport_10042007.html

  11. OSHA Releases Pandemic Guidance for Healthcare Personnel (05-24-2007)

    CBN Report: OSHA released Pandemic Influenza Preparedness and Response Guidance for Healthcare Workers and Healthcare Employers which provides a concise yet comprehensive overview of the occupational health issues related to hospital pandemic prep.
    Thu, 24 May 2007 15:17:19 GMThttp://www.upmc-cbn.org/report_archive/2007/05_May_2007/cbnreport_05242007.html

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Prevention, Diagnosis, and Treatment of Diseases

CBN Prevention, Diagnosis, and Treatment of Disease

Clinicians' Biosecurity Network Report archive for prevention, diagnosis, and treatment of disease.

  1. Hong Kong Study Finds that Closing Schools May Not Have Helped Slow the Spread of Flu (09-26-2008)

    A new study published in Emerging Infectious Diseases (EID) suggests that Hong Kong�s efforts to close schools for two weeks during the 2008 influenza season may have done little to limit the community-wide spread of influenza.
    Fri, 26 Sep 2008 19:21:39 GMThttp://www.upmc-cbn.org/report_archive/2008/09_September_2008/cbnreport_09262008.html

  2. CDC Publishes Report on Meeting of Experts to Update Guidelines for Management of Anthrax (04-14-2008)

    2008: CDC convened subjects matter experts to review and update guidelines for anthrax TX and make consensus recommendations for updating guidelines for PEP, TX, and clinical eval of patients. Read summary of EID's report.
    Mon, 14 Apr 2008 19:36:17 GMThttp://www.upmc-cbn.org/report_archive/2008/04_April_2008/cbnreport_04142008.html

  3. Progress Toward the Development of a Universal Influenza Vaccine (02-01-2008)

    Acambis , a vaccine development company, announced positive preliminary results from two studies of its universal influenza vaccine, ACAM-FLU-A
    Fri, 01 Feb 2008 15:26:45 GMThttp://www.upmc-cbn.org/report_archive/2008/02_February_2008/cbnreport_02012008.html

  4. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 17:47:46 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  5. Seasonal Flu Vaccination May Offer Partial Immunity to H5N1 (02-21-2007)

    mice vaccinated with the N1 used in seasonal flu vaccine, had significantly reduced mortality when challenged with H5N1. Some people who have had seasonal influenza vaccination carry antibodies that react to the N1 in the avian H5N1 virus
    Wed, 21 Feb 2007 19:58:37 GMThttp://www.upmc-cbn.org/report_archive/2007/02_February_2007/cbnreport_02212007.html

  6. Influenza Update: Diagnostic Test, Drug Resistance, and Possible Drug Interaction (11-16-2006)

    Researchers at the University of Colorado, the CDC, and InDevR, LLC have designed a gene chip assay that can identify and subtype Influenza A virus, distinguishing, for example, between H3N2 and H5N1 in less than 7 hours.
    Thu, 16 Nov 2006 14:54:00 GMThttp://www.upmc-cbn.org/report_archive/2006/11_November_2006/cbnreport_111606.html

  7. Smallpox Antiviral Effective in Animal Trials (10-23-2006)

    On October 18, 2006, SIGA Technologies, Inc. announced that its antiviral drug candidate SIGA-246 demonstrated a high degree of protection against variola, the smallpox virus, in a primate trial conducted at the CDC.
    Mon, 23 Oct 2006 18:45:00 GMThttp://www.upmc-cbn.org/report_archive/2006/10_October_2006/cbnreport_102306.html

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Public Health Preparedness

CBN Public Health Preparedness

Clinicians' Biosecurity Network Report archive for public health preparedness.

  1. The Role of Bacterial Pneumonia in Pandemic Influenza (09-12-2008)

    A paper by researchers from NIAID concludes that most deaths during the 1918 flu pandemic appear to have involved bacterial pneumonia rather than purely viral pneumonia. This has important implications for pandemic flu planning now.
    Fri, 12 Sep 2008 20:58:00 GMThttp://www.upmc-cbn.org/report_archive/2008/09_September_2008/cbnreport_09122008.html

  2. Utility of Antivirals During a Pandemic: Uncertainties Persist (07-30-2008)

    During a pandemic, neuraminidase inhibitors will be the antivirals of choice. But there remains uncertainty about their usefulness because access may be limited, resistance may develop, the dose and duration of treatment is uncertain, etc.
    Wed, 30 Jul 2008 14:39:20 GMThttp://www.upmc-cbn.org/report_archive/2008/07_July_2008/cbnreport_07302008.html

  3. AHRQ Releases Report on Home Healthcare During a Pandemic (07-14-2008)

    CBN Report: On July 8, 2008, the Department of Health and Human Services (HHS) Agency for Healthcare, Research and Quality (AHRQ) released a report on the issues and resources associated with home healthcare during a pandemic.
    Mon, 14 Jul 2008 18:22:10 GMThttp://www.upmc-cbn.org/report_archive/2008/07_July_2008/cbnreport_07142008.html

  4. Definitive Care for the Critically Ill During a Disaster: Report of the Task Force for Mass Critical Care of the American College of Chest Physicians Released (05-15-2008)

    Reviews preparedness for mass critical care; suggests an alternative approach to provide only essential critical care; specifies types of equipment, staffing, and space required; and suggests a framework for allocation of scarce critical care resources.
    Thu, 15 May 2008 16:18:30 GMThttp://www.upmc-cbn.org/report_archive/2008/05_May_2008/cbnreport_05152008.html

  5. Indonesia Conducts 3-Day Drill of Pandemic Influenza National Response Plan (05-01-2008)

    Indonesia holds large scale pandemic influenza drill, April 25 - April 27, 2008.
    Thu, 01 May 2008 19:58:31 GMThttp://www.upmc-cbn.org/report_archive/2008/05_May_2008/cbnreport_05012008.html

  6. ASPR Makes First Playbook Available (03-28-2008)

    DHHS/ASPR has published the first in a planned series of playbooks addressing response to disasters and other large scale emergencies.
    Fri, 28 Mar 2008 19:15:00 GMThttp://www.upmc-cbn.org/report_archive/2008/03_March_2008/cbnreport_03282008.html

  7. The Use of MedKits to Augment Rapid Distribution of Antibiotics after an Anthrax Attack (03-14-2008)

    CBN Report: Following an anthrax attack, many lives could be saved by timely distribution of antibiotics to exposed populations.
    Fri, 14 Mar 2008 21:14:54 GMThttp://www.upmc-cbn.org/report_archive/2008/03_March_2008/cbnreport_03142008.html

  8. California Releases Healthcare Surge Guidelines (02-29-2008)

    On February 19, 2008, the California Department of Public Health released its Standards and Guidelines for Healthcare Surge during Emergencies.
    Fri, 29 Feb 2008 20:37:23 GMThttp://www.upmc-cbn.org/report_archive/2008/02_February_2008/cbnreport_022908.html

  9. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 21:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  10. White House Releases HSPD 21: National Strategy for Public Health and Medical Preparedness (10-19-2007)

    This directive addresses preparedness for catastrophic health events . . . which result in a number of ill or injured persons sufficient to overwhelm the capabilities of immediate local and regional emergency response and health care systems.
    Fri, 19 Oct 2007 20:50:15 GMThttp://www.upmc-cbn.org/report_archive/2007/10_October_2007/cbnreport_10192007.html

  11. IOM Releases Pandemic PPE Report (10-04-2007)

    CBN Report: IOM released a report entitled, "Preparing for an Influenza Pandemic: PPE for Healthcare Workers" stating that the regulatory, certification, and evaluation requirements for PPE need to be revisited to ensure PPE are safe and effective.
    Thu, 04 Oct 2007 20:00:05 GMThttp://www.upmc-cbn.org/report_archive/2007/10_October_2007/cbnreport_10042007.html

  12. New System Promises Access to Prescription Information in a Disaster (04-26-2007)

    CBN Report: Descriptions of new internet-based service, Emergency RxHistory, that will provide prescribers and pharmacists access to the medication histories of patients displaced by a disaster from any internet connection.
    Thu, 26 Apr 2007 16:51:15 GMThttp://www.upmc-cbn.org/report_archive/2007/04_April_2007/cbnreport_04262007.html

  13. CDC Releases Interim Planning Guidance for Mitigation of Pandemic Influenza (02-07-2007):

    CBN Report: The CDC released its disease containment strategy for pandemic flu: Interim Pre-pandemic Planning Guidance: Community Strategy for pandemic Influenza Mitigation in the United States.
    Wed, 07 Feb 2007 19:34:49 GMThttp://www.upmc-cbn.org/report_archive/2007/02_February_2007/cbnreport_02072007.html

  14. Passage of S. 3678-The Pandemic and All-Hazards Preparedness Act (12-20-2006)

    Summary of the details of the passage of S. 3678: The Pandemic and All-Hazards Preparedness Act.
    Wed, 20 Dec 2006 15:05:00 GMThttp://www.upmc-cbn.org/report_archive/2006/12_December_2006/cbnreport_122006.html

  15. 500,000 Doses of Attenuated Smallpox Vaccine Delivered to U.S. Government (12-07-2005)

    In September 2004, Acambis was awarded a contract by the NIAID to develop and manufacture a modified Vaccinia Ankara (MVA) smallpox vaccine.
    Wed, 07 Dec 2005 20:14:00 GMThttp://www.upmc-cbn.org/report_archive/2005/12_December_2005/cbnreport_120705.html

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Swine Influenza 2009

CBN Report Swine Flu

Clinicians' Biosecurity Network Report archive for swine flu updates.

  1. 05-22-09: Clinical Details of 2009 H1N1 in Hospitalized Patients

    Important clinical details about the more severely affected 2009 H1N1 patients are beginning to emerge. These details of hospitalized patients are vital information for clinicians who may need to manage other patients.
    Fri, 22 May 2009 14:08:20 GMThttp://www.upmc-cbn.org/report_archive/2009/h1n1/05-09_Swine_Flu/cbnreport_SFhospitalized_patients-05-22-09.html

  2. 05-04-2009: Clinical Details of 2009 H1N1 Influenza Cases Emerge

    As cases of 2009 H1N1 influenza continue to accrue worldwide, more clinical information has become available and is useful in guiding the medical management of these patients.
    Mon, 04 May 2009 18:43:16 GMThttp://www.upmc-cbn.org/report_archive/2009/h1n1/05-09_Swine_Flu/cbnreport_SF8_5-04-09_AM.html

  3. 04-28-2009: Border Closures * Rapid Flu Tests * EUAs and Diagnostic Tests * Epi Update * Guidance from CDC * Guidance from WHO

    Center for Biosecurity Swine Flu Update (4-28-09): Rapid Flu Tests Have Limited Utility * FDA Issues Authorizations for EUAs and Diagnostic Tests * Epi Update * Updated Guidance from CDC * New Guidance from WHO
    Tue, 28 Apr 2009 14:03:00 GMThttp://www.upmc-cbn.org/report_archive/2009/h1n1/04-09_Swine_Flu/cbnreport_SF6_4-28-09_PM.html

  4. 04-27-2009: WHO Raises Pandemic Alert Level * EU Issues Travel Advisories for United States and Mexico * Additional Cases in NYC and Other Countries * Updated Guidance from CDC

    Monday, 4-27 | 6:00 PM -- WHO Raises Pandemic Alert Level * EU Issues Travel Advisories for United States and Mexico * Additional Cases in NYC and Other Countries * Updated Guidance from CDC (Center for Biosecurity of UPMC)
    Mon, 27 Apr 2009 23:34:30 GMThttp://www.upmc-cbn.org/report_archive/2009/h1n1/04-09_Swine_Flu/cbnreport_SF5_4-27-09_PM.html

  5. 04-26-2009: CDC/DHS Press conference; WHO pandemic alert level; epidemiology update

    Sunday, 4-26 | 7:00 PM -- CDC/DHS Press Conference; WHO pandemic alert level; Epidemiology Update
    Sun, 26 Apr 2009 23:21:49 GMThttp://www.upmc-cbn.org/report_archive/2009/h1n1/04-09_Swine_Flu/cbnreport_SF4_4-26-09_PM.html

  6. 04-25-2009: New developments; WHO pandemic alert levels; key questions

    Media outlets are reporting this afternoon that confirmed and probable cases of the new strain of H1N1 swine influenza have been discovered in Kansas, New York, and California.
    Sun, 26 Apr 2009 19:15:48 GMThttp://www.upmc-cbn.org/report_archive/2009/h1n1/04-09_Swine_Flu/cbnreport_SF3_4-25-09_PM.html

  7. 04-24-2009: Mexico cases; U.S. cases; info. CDC has confirmed; key questions

    Since earlier CBN rpt, various news articles citing officials from the WHO have reported approx. 60 fatalities and 100s cases of suspected swine flu A in humans in Mexico. Still no official confirmation of number cases or deaths.
    Sun, 26 Apr 2009 18:46:48 GMThttp://www.upmc-cbn.org/report_archive/2009/h1n1/04-09_Swine_Flu/cbnreport_SF2_4-24-09_PM.html

  8. 04-24-2009: Swine Flu Cases Without Swine Exposure

    On 4/21/2009, the CDC described 2 cases of swine flu A (H1N1) infection in Southern CA in April. While both patients recovered uneventfully, the isolated viruses harbor novel genetic characteristics not seen in the U.S. prior to this event.
    Sun, 26 Apr 2009 18:46:06 GMThttp://www.upmc-cbn.org/report_archive/2009/h1n1/04-09_Swine_Flu/cbnreport_SF1_4-24-09_AM.html

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Science and Biosecurity

CBN Science and Biosecurity

Clinicians' Biosecurity Network Report archive for science and biosecurity.

  1. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 21:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  2. National Academies Report on Boston BSL-4 Laboratory (11-30-2007)

    Yesterday, a National Research Council (NRC) committee deemed an NIH risk analysis for a proposed biocontainment laboratory at Boston University to be "not sound and credible."
    Fri, 30 Nov 2007 21:37:00 GMThttp://www.upmc-cbn.org/report_archive/2007/11_November_2007/cbnreport_11302007.html

  3. Influenza Update: Diagnostic Test, Drug Resistance, and Possible Drug Interaction (11-16-2006)

    Researchers at the University of Colorado, the CDC, and InDevR, LLC have designed a gene chip assay that can identify and subtype Influenza A virus, distinguishing, for example, between H3N2 and H5N1 in less than 7 hours.
    Thu, 16 Nov 2006 14:54:00 GMThttp://www.upmc-cbn.org/report_archive/2006/11_November_2006/cbnreport_111606.html

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