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Clinitians' Biosecurity Network
  
Emergency Resources

 

This Website is supported by funding from the Alfred P. Sloan Foundation.

CBN Report Archive 

Organized by Topic | by Date

This archive lists CBN Reports published within the past 18 months, organized by topic.

Agents and Diseases

CBN Agents and Diseases

Clinicians' Biosecurity Network Report archive for biosecurity agents and diseases.

  1. Anthrax Cases Among Heroin Users in Europe Illustrate Novel Risk (01-22-2010)

    Bacillus anthracis, a ubiquitous but deadly pathogen found in soil, has been primarily an occupational disease, with some exceptions. Recent cases of anthrax, some fatal, in Scotland and Germany highlight a new risk--recreational heroin use.
    Fri, 22 Jan 2010 15:49:15 GMThttp://www.upmc-cbn.org/report_archive/2010/01Jan_2010/cbnreport_01222010.html

  2. Unusual Case of GI Anthrax in New Hampshire Raises Questions (01-08-2010)

    On December 26, 2009, the New Hampshire Department of Health and Human Services announced that a female member of a drumming group was diagnosed with gastrointestinal anthrax, presumably contracted at an event held on December 4.
    Fri, 08 Jan 2010 12:14:40 GMThttp://www.upmc-cbn.org/report_archive/2010/01Jan_2010/cbnreport_01082010.html

  3. Adenovirus 14: An Emerging Threat (04-17-2009)

    The Journal of Infectious Disease has just published 2 papers by teams of researchers describing separate, severe outbreaks of Adenovirus 14 (Ad14), a historically rare serotype of adenovirus that has not been known to cause severe disease.
    Fri, 17 Apr 2009 15:42:36 GMThttp://www.upmc-cbn.org/report_archive/2009/04_April_2009/cbnreport_04172009.html

  4. 3rd Generation Smallpox Vaccine LC16m8 Proved Safe and Immunogenic (03-20-2009)

    New JAMA study from Japanese researchers testing LC16m8, tissue-cultured 3rd gen smallpox vaccine. Overall, the vaccine displayed high levels of vaccine take in primary vaccinees and provoked an effective booster response in some revaccinees.
    Fri, 20 Mar 2009 14:31:31 GMThttp://www.upmc-cbn.org/report_archive/2009/03_March_2009/cbnreport_03202009.html

  5. Longer Treatment Window for Botulism (02-20-2009)

    Results from a new study published in JID demonstrate the persistence of botulinum toxin in the serum of patients up to 11 days after exposure. The prolonged persistence of toxin allows for admin of anti-toxin as long 12 days after toxin ingestion
    Fri, 20 Feb 2009 18:53:50 GMThttp://www.upmc-cbn.org/report_archive/2009/02_February_2009/cbnreport_02202009.html

  6. Update on Smallpox Vaccine (01-08-2009)

    The 2001 anthrax attacks spurred new vaccine development, and, as a result, there have been several updates to the smallpox vaccine armamentarium, which are reviewed here.
    Fri, 09 Jan 2009 14:42:32 GMThttp://www.upmc-cbn.org/report_archive/2009/01_January_2009/cbnreport_01092009.html

  7. Long-lived Immunity after Smallpox Vaccination (12-05-2008)

    Researchers from NIA have just reported results of a study in which 97% of 209 vaccinated subjects maintained antibody titers for up to 88 years. While promising, these results must be interpreted carefully.
    Fri, 05 Dec 2008 15:05:41 GMThttp://www.upmc-cbn.org/report_archive/2008/12_December_2008/cbnreport_12052008.html

  8. New Arenavirus Identified as Cause of Cluster of Illness and Death in South Africa and Zambia (11-07-2008)

    Through molecular diagnostic techniques, a previously unknown arenavirus has been identified as the etiologic agent responsible for 4 deaths in Africa that occurred in September and October of 2008.
    Fri, 07 Nov 2008 21:12:16 GMThttp://www.upmc-cbn.org/report_archive/2008/11_November_2008/cbnreport_11072008.html

  9. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 22:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  10. HHS Award Multiple Contracts for Anthrax Countermeasures (09-28-2007)

    CBN Report: BARDA awarded contracts for advanced development of anthrax countermeasures Anthim and Valortim. BARDA also awarded a purchase contract for BioThrax anthrax vaccine.
    Mon, 01 Oct 2007 14:32:31 GMThttp://www.upmc-cbn.org/report_archive/2007/09_September_2007/cbnreport_09282007.html

  11. The Potential Disaster of Extensively Drug Resistant Tuberculosis (11-10-2006)

    At the recent meeting of the IDSA in Toronto (October 12-15, 2006), Dr. Henry Blumberg of the Emory University School of Medicine presented a comprehensive review of tuberculosis in the world. The picture is grim.
    Fri, 10 Nov 2006 15:43:00 GMThttp://www.upmc-cbn.org/report_archive/2006/11_November_2006/cbnreport_111006.html

  12. Smallpox Antiviral Effective in Animal Trials (10-23-2006)

    On October 18, 2006, SIGA Technologies, Inc. announced that its antiviral drug candidate SIGA-246 demonstrated a high degree of protection against variola, the smallpox virus, in a primate trial conducted at the CDC.
    Mon, 23 Oct 2006 21:15:00 GMThttp://www.upmc-cbn.org/report_archive/2006/10_October_2006/cbnreport_102306.html

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Avian/Pandemic Influenza

CBN Avian-Pandemic Flu

Clinicians' Biosecurity Network Report archive for avian, pandemic flu.

  1. ACIP Endorses Universal Flu Vaccination (03-03-2010)

    The U.S. Advisory Committee on Immunization Practices (ACIP) voted unanimously to recommend that the entire U.S. population receive annual influenza vaccination, with the exception of children under 6 months of age.
    Thu, 04 Mar 2010 21:26:04 GMThttp://www.upmc-cbn.org/report_archive/2010/03Mar_2010/cbnreport_03032010.html

  2. Hospital Response to the 2009 Influenza Pandemic: A Survey of U.S. Hospital Epidemiologists (02-19-2010)

    Hospital Response to 2009 Flu Pandemic: Authors of a recent study report results of survey of hospital epidemiologists�overall, hospitals were prepared, but other activities suffered; antiviral shortages common; sustained airborne precautions not favored.
    Fri, 19 Feb 2010 17:10:54 GMThttp://www.upmc-cbn.org/report_archive/2010/02Feb_2010/cbnreport_02192010.html

  3. H5N1 Remains a Pandemic Threat (02-05-2010)

    The world�s attention has been focused on the H1N1 pandemic, which has been less severe than feared; however, the original threat of an H5N1 influenza pandemic remains, even while overshadowed by the actual 2009 pandemic.
    Fri, 05 Feb 2010 15:08:57 GMThttp://www.upmc-cbn.org/report_archive/2010/02Feb_2010/cbnreport_02052010.html

  4. Antigenic Drift is Not the Sole Factor Driving Evolution of the Influenza Virus (10-30-2009)

    Evolution of seasonal flu A viruses has long been attributed solely to antigenic drift; however, a new study by a team of researchers from the NIH demonstrates that the process is more complex than previously thought.
    Fri, 30 Oct 2009 14:23:13 GMThttp://www.upmc-cbn.org/report_archive/2009/10_October_2009/cbnreport_10302009.html

  5. Critical Care of H1N1 Influenza A Patients (10-16-2009)

    Reports now emerging from the Southern Hemisphere, and a few other areas, are beginning to paint a clearer picture of both the clinical manifestation of severe H1N1 influenza disease and actual utilization of critical care resources.
    Fri, 16 Oct 2009 13:45:45 GMThttp://www.upmc-cbn.org/report_archive/2009/10_October_2009/cbnreport_10162009.html

  6. Clinical Aspects of H1N1 Influenza A Infection (10-14-2009)

    Several research reports detailing aspects of infection with the pandemic strain of influenza have recently been released. These reports describing clinically relevant aspects of cases are useful for day-to-day management of pandemic influenza.
    Wed, 14 Oct 2009 17:09:24 GMThttp://www.upmc-cbn.org/report_archive/2009/10_October_2009/cbnreport_10142009.html

  7. New IOM Guidance on Crisis Standards of Care for Use in Disaster Situations (10-02-2009)

    On September 24, 2009, the Institute of Medicine's (IOM) Committee on Guidance for Establishing Standards of Care for Use in Disaster Situations released Guidance for Establishing Crisis Standards of Care for Use in Disaster Situations: A Letter Report.
    Fri, 02 Oct 2009 16:38:52 GMThttp://www.upmc-cbn.org/report_archive/2009/10_October_2009/cbnreport_10022009.html

  8. Single-Dose Vaccination for the 2009 H1N1 Influenza A Virus (09-15-2009)

    Two studies published ahead of print in the New England Journal of Medicine provide evidence that a single dose of vaccine may be sufficient for the 2009 H1N1 influenza A.
    Tue, 15 Sep 2009 19:24:03 GMThttp://www.upmc-cbn.org/report_archive/2009/09_September_2009/cbnreport_09152009.html

  9. H1N1 Dual Infections (09-04-2009)

    As the world is currently in the midst of a WHO stage VI pandemic with the 2009 H1N1 influenza virus, it remains a possibility that this virus could reassort with other flu strains--most notably, the WHO stage III pandemic H5N1 avian influenza virus.
    Fri, 04 Sep 2009 17:35:24 GMThttp://www.upmc-cbn.org/report_archive/2009/09_September_2009/cbnreport_09042009.html

  10. Zanamivir Resistance in Influenza (08-14-2009)

    Antiviral therapy against influenza always has been plagued by the development of resistance. Unfortunately, as medical mngmnt of flu relies increasingly on antiviral therapy, resistance will become more commonplace, and may render some drugs obsolete.
    Fri, 14 Aug 2009 16:12:42 GMThttp://www.upmc-cbn.org/report_archive/2009/08_August_2009/cbnreport_08142009

  11. A Novel H3N2 Influenza A Variant Emerges (07-31-2009)

    A new H3N2 variant has emerged that may be poorly matched to the 2009 seasonal flu vaccine. This could pose a risk to the elderly and to those who have been vaccinated against the pandemic strain.
    Fri, 31 Jul 2009 18:41:00 GMThttp://www.upmc-cbn.org/report_archive/2009/07_July_2009/cbnreport_07312009.html

  12. 2009 H1N1 Influenza A: Clinical Details, Antiviral Resistance, and Other Mutations (07-17-09)

    Several scientific papers have been published recently that elucidate both the spectrum of illness caused by the 2009 H1N1 influenza (A) virus and its ability to evade antiviral drugs.
    Fri, 17 Jul 2009 16:39:39 GMThttp://www.upmc-cbn.org/report_archive/2009/07_July_2009/cbnreport_07172009.html

  13. Healthcare Workers at Risk for H1N1 Infection (06-19-2009)

    There have been cases of the 2009 H1N1 influenza (A) virus among healthcare workers, as detailed in the June 19, 2009 MMWR. It appears that all could have been prevented had standard infection control measures been taken.
    Fri, 19 Jun 2009 15:07:00 GMThttp://www.upmc-cbn.org/report_archive/2009/06_June_2009/cbnreport_06192009.html

  14. H7-subtype Influenza Infections: Pandemic Potential? (06-05-2009)

    However, the pandemic potential of the H7 viruses cannot be overlooked. While they are not nearly as lethal as H5N1, a pandemic need not cause mass lethality to have a significant impact around the globe.
    Fri, 05 Jun 2009 18:48:59 GMThttp://www.upmc-cbn.org/report_archive/2009/06_June_2009/cbnreport_06052009.html

  15. Swine Flu Cases Without Swine Exposure (04-24-2009)

    On 4/21/2009, the CDC described 2 cases of swine flu A (H1N1) infection in Southern CA in April. While both patients recovered uneventfully, the isolated viruses harbor novel genetic characteristics not seen in the U.S. prior to this event.
    Fri, 24 Apr 2009 14:26:22 GMThttp://www.upmc-cbn.org/report_archive/h1n1/04-09_Swine_Flu/cbnreport_SF1_4-24-09_AM.html

  16. Oseltamivir Protective Against Influenza-induced Cardiac Events (04-03-2009)

    A new study finds that antiviral therapy can reduce cardiovascular complications following influenza infection in patients with previous cardiac disease.
    Thu, 02 Apr 2009 22:41:56 GMThttp://www.upmc-cbn.org/report_archive/2009/04_April_2009/cbnreport_04032009

  17. Broad-spectrum Flu Antibodies Characterized (03-06-2009)

    Two teams of researchers recently and simultaneously reported discovery and development of antibodies generated against invariate regions of the influenza virus.
    Fri, 06 Mar 2009 20:10:52 GMThttp://www.upmc-cbn.org/report_archive/2009/03_March_2009/cbnreport_03062009

  18. Global Avian influenza Panzootic Continues; Some Preparedness Gains Made but Hospitals Remain Vulnerable (02-06-2009)

    Although "bird flu" has not been featured prominently on the evening news of late, the influenza A/H5N1 panzootic continues. And, as has been true since this global outbreak erupted in Thailand and Vietnam, it remains distinctly seasonal in nature.
    Fri, 06 Feb 2009 20:13:05 GMThttp://www.upmc-cbn.org/report_archive/2009/02_February_2009/cbnreport_02062009.html

  19. Is Airborne Spread of Influenza Possible? (01-22-2009)

    A new study demonstrates that the flu virus is able to remain suspended in the air, thus enabling airborne transmission. This finding suggests the possible need for more stringent infection control measures to forestall spread of flu in hospitals.
    Thu, 22 Jan 2009 21:10:34 GMThttp://www.upmc-cbn.org/report_archive/2009/01_January_2009/cbnreport_01222009.html

  20. Update on Personal Protective Equipment (12-19-2008)

    Two recent studies raise questions about best use of PPE and assumptions underlying related current recommendations.
    Fri, 19 Dec 2008 21:43:12 GMThttp://www.upmc-cbn.org/report_archive/2008/12_December_2008/cbnreport_12192008.html

  21. Modeling Drug Resistant Influenza (11-21-2008)

    In a new mathematical modeling study Brockmann and colleagues report that drug resistant influenza was capable of increasing hospitalization rates by up to 233% in a hypothetical Swiss town of 100,000 inhabitants.
    Mon, 24 Nov 2008 16:44:28 GMThttp://www.upmc-cbn.org/report_archive/2008/11_November_2008/cbnreport_11212008.html

  22. Rising Staphylococcus aureus Co-infection among Pediatric Influenza Deaths (10-10-2008)

    The results of a study of pediatric flu mortality for 3 flu seasons, by CDC investigators, were published recently. The authors report an increase in the incidence of bacterial co-infection in fatal pediatric flu from 6 to 34 percent in that period.
    Fri, 10 Oct 2008 16:08:11 GMThttp://www.upmc-cbn.org/report_archive/2008/10_October_2008/cbnreport_10092008.html

  23. Hong Kong Study Finds that Closing Schools May Not Have Helped Slow the Spread of Flu (09-26-2008)

    A new study published in Emerging Infectious Diseases (EID) suggests that Hong Kong�s efforts to close schools for two weeks during the 2008 influenza season may have done little to limit the community-wide spread of influenza.
    Fri, 26 Sep 2008 20:21:39 GMThttp://www.upmc-cbn.org/report_archive/2008/09_September_2008/cbnreport_09262008.html

  24. The Role of Bacterial Pneumonia in Pandemic Influenza (09-12-2008)

    A paper by researchers from NIAID concludes that most deaths during the 1918 flu pandemic appear to have involved bacterial pneumonia rather than purely viral pneumonia. This has important implications for pandemic flu planning now.
    Fri, 12 Sep 2008 21:58:00 GMThttp://www.upmc-cbn.org/report_archive/2008/09_September_2008/cbnreport_09122008.html

  25. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 18:47:46 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  26. Evidence for a Heritable Predisposition to Fatal Influenza (12-19-2007)

    CBN Report: A recent study by Albright and colleagues from the University of Utah School of Medicine supports the hypothesis that there exists an inherited predisposition to developing and dying from severe influenza.
    Wed, 19 Dec 2007 19:39:00 GMThttp://www.upmc-cbn.org/report_archive/2007/12_December_2007/cbnreport_12192007.html

  27. Estimate of the Financial Effect of a Flu Pandemic on U.S. Hospitals (12-07-2007)

    CBN Report: Center for Biosecurity estimates potential financial impact of a flu pandemic on U.S. hospitals to be approximately $785,000 for average U.S. hospital, and $3.9 billion total for all U.S. hospitals.
    Fri, 07 Dec 2007 19:37:25 GMThttp://www.upmc-cbn.org/report_archive/2007/12_December_2007/cbnreport_12072007

  28. Recent H5N1 Developments (10-15-2007)

    CBN Report: Recent articles shed light on the virulence and pathogenesis of H5N1 and suggest a possible new approach to treatment.
    Mon, 15 Oct 2007 16:21:54 GMThttp://www.upmc-cbn.org/report_archive/2007/10_October_2007/cbnreport_10152007.html

  29. IOM Releases Pandemic PPE Report (10-04-2007)

    CBN Report: IOM released a report entitled, "Preparing for an Influenza Pandemic: PPE for Healthcare Workers" stating that the regulatory, certification, and evaluation requirements for PPE need to be revisited to ensure PPE are safe and effective.
    Thu, 04 Oct 2007 21:00:05 GMThttp://www.upmc-cbn.org/report_archive/2007/10_October_2007/cbnreport_10042007.html

  30. Passive Immunization with Human Monoclonal Antibodies in H5N1 (05-30-2007)

    CBN Report: Passive immunotherapy with neutralizing H5N1 human monoclonal antibodies (mAbs) is effective in preventing and treating H5N1 infection in a murine model.
    Wed, 30 May 2007 17:03:23 GMThttp://www.upmc-cbn.org/report_archive/2007/05_May_2007/cbnreport_05302007.html

  31. OSHA Releases Pandemic Guidance for Healthcare Personnel (05-24-2007)

    CBN Report: OSHA released Pandemic Influenza Preparedness and Response Guidance for Healthcare Workers and Healthcare Employers which provides a concise yet comprehensive overview of the occupational health issues related to hospital pandemic prep.
    Thu, 24 May 2007 16:17:19 GMThttp://www.upmc-cbn.org/report_archive/2007/05_May_2007/cbnreport_05242007.html

  32. Seasonal Flu Vaccination May Offer Partial Immunity to H5N1 (02-21-2007)

    mice vaccinated with the N1 used in seasonal flu vaccine, had significantly reduced mortality when challenged with H5N1. Some people who have had seasonal influenza vaccination carry antibodies that react to the N1 in the avian H5N1 virus
    Wed, 21 Feb 2007 20:58:37 GMThttp://www.upmc-cbn.org/report_archive/2007/02_February_2007/cbnreport_02212007.html

  33. CDC Releases Interim Planning Guidance for Mitigation of Pandemic Influenza (02-07-2007):

    CBN Report: The CDC released its disease containment strategy for pandemic flu: Interim Pre-pandemic Planning Guidance: Community Strategy for pandemic Influenza Mitigation in the United States.
    Wed, 07 Feb 2007 20:34:48 GMThttp://www.upmc-cbn.org/report_archive/2007/02_February_2007/cbnreport_02072007.html

  34. Influenza Update: Diagnostic Test, Drug Resistance, and Possible Drug Interaction (11-16-2006)

    Researchers at the University of Colorado, the CDC, and InDevR, LLC have designed a gene chip assay that can identify and subtype Influenza A virus, distinguishing, for example, between H3N2 and H5N1 in less than 7 hours.
    Thu, 16 Nov 2006 21:22:00 GMThttp://www.upmc-cbn.org/report_archive/2006/11_November_2006/cbnreport_111606.html

  35. Smallpox Antiviral Effective in Animal Trials (10-23-2006)

    On October 18, 2006, SIGA Technologies, Inc. announced that its antiviral drug candidate SIGA-246 demonstrated a high degree of protection against variola, the smallpox virus, in a primate trial conducted at the CDC.
    Mon, 23 Oct 2006 19:45:00 GMThttp://www.upmc-cbn.org/report_archive/2006/10_October_2006/cbnreport_102306.html

  36. Predicting the Impact of a Flu Epidemic (12-01-2005)

    On November 7, 2005 the CDC released a new version of its FluSurge program which . . . calculates the impact on hospital capacity over the course of an epidemic . . .
    Thu, 01 Dec 2005 21:15:00 GMThttp://www.upmc-cbn.org/report_archive/2005/12_December_2005/cbnreport_120105.html

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Countermeasure Development

CBN Countermeasure Developments

Clinicians' Biosecurity Network Report archive for countermeasure development.

  1. Single-Dose Vaccination for the 2009 H1N1 Influenza A Virus (09-15-2009)

    Two studies published ahead of print in the New England Journal of Medicine provide evidence that a single dose of vaccine may be sufficient for the 2009 H1N1 influenza A.
    Tue, 15 Sep 2009 19:24:03 GMThttp://www.upmc-cbn.org/report_archive/2009/09_September_2009/cbnreport_09152009.html

  2. 3rd Generation Smallpox Vaccine LC16m8 Proved Safe and Immunogenic (03-20-2009)

    New JAMA study from Japanese researchers testing LC16m8, tissue-cultured 3rd gen smallpox vaccine. Overall, the vaccine displayed high levels of vaccine take in primary vaccinees and provoked an effective booster response in some revaccinees.
    Fri, 20 Mar 2009 14:31:31 GMThttp://www.upmc-cbn.org/report_archive/2009/03_March_2009/cbnreport_03202009.html

  3. Update on Smallpox Vaccine (01-08-2009)

    The 2001 anthrax attacks spurred new vaccine development, and, as a result, there have been several updates to the smallpox vaccine armamentarium, which are reviewed here.
    Fri, 09 Jan 2009 14:42:32 GMThttp://www.upmc-cbn.org/report_archive/2009/01_January_2009/cbnreport_01092009.html

  4. Long-lived Immunity after Smallpox Vaccination (12-05-2008)

    Researchers from NIA have just reported results of a study in which 97% of 209 vaccinated subjects maintained antibody titers for up to 88 years. While promising, these results must be interpreted carefully.
    Fri, 05 Dec 2008 15:05:41 GMThttp://www.upmc-cbn.org/report_archive/2008/12_December_2008/cbnreport_12052008.html

  5. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 22:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  6. Smallpox Antiviral Effective in Animal Trials (10-23-2006)

    On October 18, 2006, SIGA Technologies, Inc. announced that its antiviral drug candidate SIGA-246 demonstrated a high degree of protection against variola, the smallpox virus, in a primate trial conducted at the CDC.
    Mon, 23 Oct 2006 21:15:00 GMThttp://www.upmc-cbn.org/report_archive/2006/10_October_2006/cbnreport_102306.html

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Government Policy and Programs

CBN Government Policy and Programs

Clinicians' Biosecurity Network Report archive for government policy and programs.

  1. New Report: The Next Challenge in Healthcare Preparedness (03-05-2010)

    The Center�s new report, The Next Challenge in Healthcare Preparedness: Catastrophic Health Events, proposes key elements of a national strategy for healthcare preparedness and response.
    Fri, 05 Mar 2010 14:52:05 GMThttp://www.upmc-cbn.org/report_archive/2010/03Mar_2010/cbnreport_03052010.html

  2. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 22:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  3. National Academies Report on Boston BSL-4 Laboratory (11-30-2007)

    Yesterday, a National Research Council (NRC) committee deemed an NIH risk analysis for a proposed biocontainment laboratory at Boston University to be "not sound and credible."
    Fri, 30 Nov 2007 21:54:00 GMThttp://www.upmc-cbn.org/report_archive/2007/11_November_2007/cbnreport_11302007.html

  4. CDC Releases Interim Planning Guidance for Mitigation of Pandemic Influenza (02-07-2007):

    CBN Report: The CDC released its disease containment strategy for pandemic flu: Interim Pre-pandemic Planning Guidance: Community Strategy for pandemic Influenza Mitigation in the United States.
    Wed, 07 Feb 2007 20:34:49 GMThttp://www.upmc-cbn.org/report_archive/2007/02_February_2007/cbnreport_02072007.html

  5. Passage of S. 3678-The Pandemic and All-Hazards Preparedness Act (12-20-2006)

    Summary of the details of the passage of S. 3678: The Pandemic and All-Hazards Preparedness Act.
    Wed, 20 Dec 2006 16:05:00 GMThttp://www.upmc-cbn.org/report_archive/2006/12_December_2006/cbnreport_122006.html

  6. 500,000 Doses of Attenuated Smallpox Vaccine Delivered to U.S. Government (12-07-2005)

    In September 2004, Acambis was awarded a contract by the NIAID to develop and manufacture a modified Vaccinia Ankara (MVA) smallpox vaccine.
    Wed, 07 Dec 2005 21:14:00 GMThttp://www.upmc-cbn.org/report_archive/2005/12_December_2005/cbnreport_120705.html

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Guidelines and Recommendations

CBN Guidelines and Recommendations

Clinicians' Biosecurity Network Report archive for guidelines and recommendations.

  1. New IOM Guidance on Crisis Standards of Care for Use in Disaster Situations (10-02-2009)

    On September 24, 2009, the Institute of Medicine's (IOM) Committee on Guidance for Establishing Standards of Care for Use in Disaster Situations released Guidance for Establishing Crisis Standards of Care for Use in Disaster Situations: A Letter Report.
    Fri, 02 Oct 2009 16:38:52 GMThttp://www.upmc-cbn.org/report_archive/2009/10_October_2009/cbnreport_10022009.html

  2. California Releases Healthcare Surge Guidelines (02-29-2008)

    On February 19, 2008, the California Department of Public Health released its Standards and Guidelines for Healthcare Surge during Emergencies.
    Fri, 29 Feb 2008 21:37:23 GMThttp://www.upmc-cbn.org/report_archive/2008/02_February_2008/cbnreport_022908.html

  3. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 22:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  4. CDC Releases Interim Planning Guidance for Mitigation of Pandemic Influenza (02-07-2007):

    CBN Report: The CDC released its disease containment strategy for pandemic flu: Interim Pre-pandemic Planning Guidance: Community Strategy for pandemic Influenza Mitigation in the United States.
    Wed, 07 Feb 2007 20:34:50 GMThttp://www.upmc-cbn.org/report_archive/2007/02_February_2007/cbnreport_02072007.html

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Hospital Preparedness

CBN Hospital Preparedness

Clinicians' Biosecurity Network Report archive for hospital preparedness.

  1. New Report: The Next Challenge in Healthcare Preparedness (03-05-2010)

    The Center�s new report, The Next Challenge in Healthcare Preparedness: Catastrophic Health Events, proposes key elements of a national strategy for healthcare preparedness and response.
    Fri, 05 Mar 2010 14:52:05 GMThttp://www.upmc-cbn.org/report_archive/2010/03Mar_2010/cbnreport_03052010.html

  2. Hospital Response to the 2009 Influenza Pandemic: A Survey of U.S. Hospital Epidemiologists (02-19-2010)

    Hospital Response to 2009 Flu Pandemic: Authors of a recent study report results of survey of hospital epidemiologists�overall, hospitals were prepared, but other activities suffered; antiviral shortages common; sustained airborne precautions not favored.
    Fri, 19 Feb 2010 17:10:54 GMThttp://www.upmc-cbn.org/report_archive/2010/02Feb_2010/cbnreport_02192010.html

  3. New IOM Guidance on Crisis Standards of Care for Use in Disaster Situations (10-02-2009)

    On September 24, 2009, the Institute of Medicine's (IOM) Committee on Guidance for Establishing Standards of Care for Use in Disaster Situations released Guidance for Establishing Crisis Standards of Care for Use in Disaster Situations: A Letter Report.
    Fri, 02 Oct 2009 16:38:52 GMThttp://www.upmc-cbn.org/report_archive/2009/10_October_2009/cbnreport_10022009.html

  4. Hospitals Are Better Prepared for Mass Casualty Disasters (05-08-2009)

    Based on interviews with 133 individuals involved with disaster preparedness in hospitals across the U.S., we found that hospitals are significantly better prepared now than in 2001; much of the improvement is attributable to the HPP.
    Fri, 08 May 2009 16:36:45 GMThttp://www.upmc-cbn.org/report_archive/2009/05_May_2009/cbnreport_05082009.html

  5. Global Avian influenza Panzootic Continues; Some Preparedness Gains Made but Hospitals Remain Vulnerable (02-06-2009)

    Although "bird flu" has not been featured prominently on the evening news of late, the influenza A/H5N1 panzootic continues. And, as has been true since this global outbreak erupted in Thailand and Vietnam, it remains distinctly seasonal in nature.
    Fri, 06 Feb 2009 20:13:05 GMThttp://www.upmc-cbn.org/report_archive/2009/02_February_2009/cbnreport_02062009.html

  6. Is Airborne Spread of Influenza Possible? (01-22-2009)

    A new study demonstrates that the flu virus is able to remain suspended in the air, thus enabling airborne transmission. This finding suggests the possible need for more stringent infection control measures to forestall spread of flu in hospitals.
    Thu, 22 Jan 2009 21:10:34 GMThttp://www.upmc-cbn.org/report_archive/2009/01_January_2009/cbnreport_01222009.html

  7. Update on Personal Protective Equipment (12-19-2008)

    Two recent studies raise questions about best use of PPE and assumptions underlying related current recommendations.
    Fri, 19 Dec 2008 21:43:12 GMThttp://www.upmc-cbn.org/report_archive/2008/12_December_2008/cbnreport_12192008.html

  8. California Releases Healthcare Surge Guidelines (02-29-2008)

    On February 19, 2008, the California Department of Public Health released its Standards and Guidelines for Healthcare Surge during Emergencies.
    Fri, 29 Feb 2008 21:37:23 GMThttp://www.upmc-cbn.org/report_archive/2008/02_February_2008/cbnreport_022908.html

  9. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 22:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  10. Estimate of the Financial Effect of a Flu Pandemic on U.S. Hospitals (12-07-2007)

    CBN Report: Center for Biosecurity estimates potential financial impact of a flu pandemic on U.S. hospitals to be approximately $785,000 for average U.S. hospital, and $3.9 billion total for all U.S. hospitals.
    Fri, 07 Dec 2007 19:37:25 GMThttp://www.upmc-cbn.org/report_archive/2007/12_December_2007/cbnreport_12072007

  11. IOM Releases Pandemic PPE Report (10-04-2007)

    CBN Report: IOM released a report entitled, "Preparing for an Influenza Pandemic: PPE for Healthcare Workers" stating that the regulatory, certification, and evaluation requirements for PPE need to be revisited to ensure PPE are safe and effective.
    Thu, 04 Oct 2007 21:00:05 GMThttp://www.upmc-cbn.org/report_archive/2007/10_October_2007/cbnreport_10042007.html

  12. OSHA Releases Pandemic Guidance for Healthcare Personnel (05-24-2007)

    CBN Report: OSHA released Pandemic Influenza Preparedness and Response Guidance for Healthcare Workers and Healthcare Employers which provides a concise yet comprehensive overview of the occupational health issues related to hospital pandemic prep.
    Thu, 24 May 2007 16:17:19 GMThttp://www.upmc-cbn.org/report_archive/2007/05_May_2007/cbnreport_05242007.html

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Prevention, Diagnosis, and Treatment of Diseases

CBN Prevention, Diagnosis, and Treatment of Disease

Clinicians' Biosecurity Network Report archive for prevention, diagnosis, and treatment of disease.

  1. Hong Kong Study Finds that Closing Schools May Not Have Helped Slow the Spread of Flu (09-26-2008)

    A new study published in Emerging Infectious Diseases (EID) suggests that Hong Kong�s efforts to close schools for two weeks during the 2008 influenza season may have done little to limit the community-wide spread of influenza.
    Fri, 26 Sep 2008 20:21:39 GMThttp://www.upmc-cbn.org/report_archive/2008/09_September_2008/cbnreport_09262008.html

  2. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 18:47:46 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  3. Seasonal Flu Vaccination May Offer Partial Immunity to H5N1 (02-21-2007)

    mice vaccinated with the N1 used in seasonal flu vaccine, had significantly reduced mortality when challenged with H5N1. Some people who have had seasonal influenza vaccination carry antibodies that react to the N1 in the avian H5N1 virus
    Wed, 21 Feb 2007 20:58:37 GMThttp://www.upmc-cbn.org/report_archive/2007/02_February_2007/cbnreport_02212007.html

  4. Influenza Update: Diagnostic Test, Drug Resistance, and Possible Drug Interaction (11-16-2006)

    Researchers at the University of Colorado, the CDC, and InDevR, LLC have designed a gene chip assay that can identify and subtype Influenza A virus, distinguishing, for example, between H3N2 and H5N1 in less than 7 hours.
    Thu, 16 Nov 2006 15:54:00 GMThttp://www.upmc-cbn.org/report_archive/2006/11_November_2006/cbnreport_111606.html

  5. Smallpox Antiviral Effective in Animal Trials (10-23-2006)

    On October 18, 2006, SIGA Technologies, Inc. announced that its antiviral drug candidate SIGA-246 demonstrated a high degree of protection against variola, the smallpox virus, in a primate trial conducted at the CDC.
    Mon, 23 Oct 2006 19:45:00 GMThttp://www.upmc-cbn.org/report_archive/2006/10_October_2006/cbnreport_102306.html

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Public Health Preparedness

CBN Public Health Preparedness

Clinicians' Biosecurity Network Report archive for public health preparedness.

  1. Unusual Case of GI Anthrax in New Hampshire Raises Questions (01-08-2010)

    On December 26, 2009, the New Hampshire Department of Health and Human Services announced that a female member of a drumming group was diagnosed with gastrointestinal anthrax, presumably contracted at an event held on December 4.
    Fri, 08 Jan 2010 12:14:40 GMThttp://www.upmc-cbn.org/report_archive/2010/01Jan_2010/cbnreport_01082010.html

  2. Single-Dose Vaccination for the 2009 H1N1 Influenza A Virus (09-15-2009)

    Two studies published ahead of print in the New England Journal of Medicine provide evidence that a single dose of vaccine may be sufficient for the 2009 H1N1 influenza A.
    Tue, 15 Sep 2009 19:24:03 GMThttp://www.upmc-cbn.org/report_archive/2009/09_September_2009/cbnreport_09152009.html

  3. The Role of Bacterial Pneumonia in Pandemic Influenza (09-12-2008)

    A paper by researchers from NIAID concludes that most deaths during the 1918 flu pandemic appear to have involved bacterial pneumonia rather than purely viral pneumonia. This has important implications for pandemic flu planning now.
    Fri, 12 Sep 2008 21:58:00 GMThttp://www.upmc-cbn.org/report_archive/2008/09_September_2008/cbnreport_09122008.html

  4. California Releases Healthcare Surge Guidelines (02-29-2008)

    On February 19, 2008, the California Department of Public Health released its Standards and Guidelines for Healthcare Surge during Emergencies.
    Fri, 29 Feb 2008 21:37:23 GMThttp://www.upmc-cbn.org/report_archive/2008/02_February_2008/cbnreport_022908.html

  5. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 22:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  6. IOM Releases Pandemic PPE Report (10-04-2007)

    CBN Report: IOM released a report entitled, "Preparing for an Influenza Pandemic: PPE for Healthcare Workers" stating that the regulatory, certification, and evaluation requirements for PPE need to be revisited to ensure PPE are safe and effective.
    Thu, 04 Oct 2007 21:00:05 GMThttp://www.upmc-cbn.org/report_archive/2007/10_October_2007/cbnreport_10042007.html

  7. New System Promises Access to Prescription Information in a Disaster (04-26-2007)

    CBN Report: Descriptions of new internet-based service, Emergency RxHistory, that will provide prescribers and pharmacists access to the medication histories of patients displaced by a disaster from any internet connection.
    Thu, 26 Apr 2007 17:51:15 GMThttp://www.upmc-cbn.org/report_archive/2007/04_April_2007/cbnreport_04262007.html

  8. CDC Releases Interim Planning Guidance for Mitigation of Pandemic Influenza (02-07-2007):

    CBN Report: The CDC released its disease containment strategy for pandemic flu: Interim Pre-pandemic Planning Guidance: Community Strategy for pandemic Influenza Mitigation in the United States.
    Wed, 07 Feb 2007 20:34:49 GMThttp://www.upmc-cbn.org/report_archive/2007/02_February_2007/cbnreport_02072007.html

  9. Passage of S. 3678-The Pandemic and All-Hazards Preparedness Act (12-20-2006)

    Summary of the details of the passage of S. 3678: The Pandemic and All-Hazards Preparedness Act.
    Wed, 20 Dec 2006 16:05:00 GMThttp://www.upmc-cbn.org/report_archive/2006/12_December_2006/cbnreport_122006.html

  10. 500,000 Doses of Attenuated Smallpox Vaccine Delivered to U.S. Government (12-07-2005)

    In September 2004, Acambis was awarded a contract by the NIAID to develop and manufacture a modified Vaccinia Ankara (MVA) smallpox vaccine.
    Wed, 07 Dec 2005 21:14:00 GMThttp://www.upmc-cbn.org/report_archive/2005/12_December_2005/cbnreport_120705.html

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2009 H1N1 Influenza

CBN Report Swine Flu

Clinicians' Biosecurity Network Report archive for swine flu updates.

  1. ACIP Endorses Universal Flu Vaccination (03-03-2010)

    The U.S. Advisory Committee on Immunization Practices (ACIP) voted unanimously to recommend that the entire U.S. population receive annual influenza vaccination, with the exception of children under 6 months of age.
    Thu, 04 Mar 2010 21:26:04 GMThttp://www.upmc-cbn.org/report_archive/2010/03Mar_2010/cbnreport_03032010.html

  2. Will the D225G Mutation Herald More Severe Illness in 2009 H1N1 Patients? (12-11-2009)

    To date, the H1N1 influenza A pandemic has been one of the mildest on record. Nonetheless, scientists have been looking for evidence of a mutation that might cause the virus to become more lethal; recently, a mutation was found in a few isolates.
    Wed, 09 Dec 2009 17:42:36 GMThttp://www.upmc-cbn.org/report_archive/2009/12_December_2009/cbnreport_12112009.html

  3. Antigenic Drift is Not the Sole Factor Driving Evolution of the Influenza Virus (10-30-2009)

    Evolution of seasonal flu A viruses has long been attributed solely to antigenic drift; however, a new study by a team of researchers from the NIH demonstrates that the process is more complex than previously thought.
    Fri, 30 Oct 2009 14:23:13 GMThttp://www.upmc-cbn.org/report_archive/2009/10_October_2009/cbnreport_10302009.html

  4. Single-Dose Vaccination for the 2009 H1N1 Influenza A Virus (09-15-2009)

    Two studies published ahead of print in the New England Journal of Medicine provide evidence that a single dose of vaccine may be sufficient for the 2009 H1N1 influenza A.
    Tue, 15 Sep 2009 19:24:03 GMThttp://www.upmc-cbn.org/report_archive/2009/09_September_2009/cbnreport_09152009.html

  5. H1N1 Dual Infections (09-04-2009)

    As the world is currently in the midst of a WHO stage VI pandemic with the 2009 H1N1 influenza virus, it remains a possibility that this virus could reassort with other flu strains--most notably, the WHO stage III pandemic H5N1 avian influenza virus.
    Fri, 04 Sep 2009 17:35:24 GMThttp://www.upmc-cbn.org/report_archive/2009/09_September_2009/cbnreport_09042009.html

  6. 2009 H1N1 Influenza A: Clinical Details, Antiviral Resistance, and Other Mutations (07-17-09)

    Several scientific papers have been published recently that elucidate both the spectrum of illness caused by the 2009 H1N1 influenza (A) virus and its ability to evade antiviral drugs.
    Fri, 17 Jul 2009 16:39:39 GMThttp://www.upmc-cbn.org/report_archive/2009/07_July_2009/cbnreport_07172009.html

  7. Healthcare Workers at Risk for H1N1 Infection (06-19-2009)

    There have been cases of the 2009 H1N1 influenza (A) virus among healthcare workers, as detailed in the June 19, 2009 MMWR. It appears that all could have been prevented had standard infection control measures been taken.
    Fri, 19 Jun 2009 15:10:00 GMThttp://www.upmc-cbn.org/report_archive/2009/06_June_2009/cbnreport_06192009.html

  8. Clinical Details of 2009 H1N1 in Hospitalized Patients (05-22-09)

    Important clinical details about the more severely affected 2009 H1N1 patients are beginning to emerge. These details of hospitalized patients are vital information for clinicians who may need to manage other patients.
    Fri, 22 May 2009 15:08:20 GMThttp://www.upmc-cbn.org/report_archive/h1n1/05-09_Swine_Flu/cbnreport_SFhospitalized_patients-05-22-09.html

  9. Clinical Details of 2009 H1N1 Influenza Cases Emerge (05-04-2009)

    As cases of 2009 H1N1 influenza continue to accrue worldwide, more clinical information has become available and is useful in guiding the medical management of these patients.
    Mon, 04 May 2009 19:43:16 GMThttp://www.upmc-cbn.org/report_archive/h1n1/05-09_Swine_Flu/cbnreport_SF8_5-04-09_AM.html

  10. Border Closures * Rapid Flu Tests * EUAs and Diagnostic Tests * Epi Update * Guidance from CDC * Guidance from WHO (04-28-2009)

    Center for Biosecurity Swine Flu Update (4-28-09): Rapid Flu Tests Have Limited Utility * FDA Issues Authorizations for EUAs and Diagnostic Tests * Epi Update * Updated Guidance from CDC * New Guidance from WHO
    Tue, 28 Apr 2009 15:03:00 GMThttp://www.upmc-cbn.org/report_archive/h1n1/04-09_Swine_Flu/cbnreport_SF6_4-28-09_PM.html

  11. WHO Raises Pandemic Alert Level * EU Issues Travel Advisories for United States and Mexico * Additional Cases in NYC and Other Countries * Updated Guidance from CDC (04-27-2009)

    Monday, 4-27 | 6:00 PM -- WHO Raises Pandemic Alert Level * EU Issues Travel Advisories for United States and Mexico * Additional Cases in NYC and Other Countries * Updated Guidance from CDC (Center for Biosecurity of UPMC)
    Tue, 28 Apr 2009 00:34:30 GMThttp://www.upmc-cbn.org/report_archive/h1n1/04-09_Swine_Flu/cbnreport_SF5_4-27-09_PM.html

  12. CDC/DHS Press conference; WHO pandemic alert level; epidemiology update (04-26-2009)

    Sunday, 4-26 | 7:00 PM -- CDC/DHS Press Conference; WHO pandemic alert level; Epidemiology Update
    Mon, 27 Apr 2009 00:21:49 GMThttp://www.upmc-cbn.org/report_archive/h1n1/04-09_Swine_Flu/cbnreport_SF4_4-26-09_PM.html

  13. New developments; WHO pandemic alert levels; key questions (04-25-2009)

    Media outlets are reporting this afternoon that confirmed and probable cases of the new strain of H1N1 swine influenza have been discovered in Kansas, New York, and California.
    Sun, 26 Apr 2009 20:15:48 GMThttp://www.upmc-cbn.org/report_archive/h1n1/04-09_Swine_Flu/cbnreport_SF3_4-25-09_PM.html

  14. Mexico cases; U.S. cases; info. CDC has confirmed; key questions (04-24-2009)

    Since earlier CBN rpt, various news articles citing officials from the WHO have reported approx. 60 fatalities and 100s cases of suspected swine flu A in humans in Mexico. Still no official confirmation of number cases or deaths.
    Sun, 26 Apr 2009 19:46:48 GMThttp://www.upmc-cbn.org/report_archive/h1n1/04-09_Swine_Flu/cbnreport_SF2_4-24-09_PM.html

  15. Swine Flu Cases Without Swine Exposure (04-24-2009)

    On 4/21/2009, the CDC described 2 cases of swine flu A (H1N1) infection in Southern CA in April. While both patients recovered uneventfully, the isolated viruses harbor novel genetic characteristics not seen in the U.S. prior to this event.
    Sun, 26 Apr 2009 19:46:06 GMThttp://www.upmc-cbn.org/report_archive/h1n1/04-09_Swine_Flu/cbnreport_SF1_4-24-09_AM.html

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Science and Biosecurity

CBN Science and Biosecurity

Clinicians' Biosecurity Network Report archive for science and biosecurity.

  1. Ten Notable Publications of 2007 (01-10-2008)

    Ten notable publications of 2007 from Center for Biosecurity of UPMC.
    Thu, 10 Jan 2008 22:08:00 GMThttp://www.upmc-cbn.org/report_archive/2008/01_January_2008/cbnreport_01102008.html

  2. National Academies Report on Boston BSL-4 Laboratory (11-30-2007)

    Yesterday, a National Research Council (NRC) committee deemed an NIH risk analysis for a proposed biocontainment laboratory at Boston University to be "not sound and credible."
    Fri, 30 Nov 2007 22:37:00 GMThttp://www.upmc-cbn.org/report_archive/2007/11_November_2007/cbnreport_11302007.html

  3. Influenza Update: Diagnostic Test, Drug Resistance, and Possible Drug Interaction (11-16-2006)

    Researchers at the University of Colorado, the CDC, and InDevR, LLC have designed a gene chip assay that can identify and subtype Influenza A virus, distinguishing, for example, between H3N2 and H5N1 in less than 7 hours.
    Thu, 16 Nov 2006 15:54:00 GMThttp://www.upmc-cbn.org/report_archive/2006/11_November_2006/cbnreport_111606.html

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Center publications links

2009 H1N1 Influenza Issue Briefs

• H1N1 and MSFWs (11-23-09)

• Vaccine Licensure & Evaluation (11-13-09)

• Surveillance (11-02-09)

• Cases, Hospitalizations, Mortality (10-22-09)

• Complete list of Issue Briefs

Center publications links

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