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Clinitians' Biosecurity Network
  
Emergency Resources

 

This Website is supported by funding from the Alfred P. Sloan Foundation.

CBN Report Archive 

Organized by Date | by Topic

This archive lists CBN Reports published within the past 18 months, organized by date.
    

February 2010

CBN February 2010

Clinicians' Biosecurity Network Report archive for February 2010.

  1. H5N1 Remains a Pandemic Threat (02-05-2010)

    The world�s attention has been focused on the H1N1 pandemic, which has been less severe than feared; however, the original threat of an H5N1 influenza pandemic remains, even while overshadowed by the actual 2009 pandemic.
    Fri, 05 Feb 2010 15:08:57 GMThttp://www.upmc-cbn.org/report_archive/2010/02Feb_2010/cbnreport_02052010.html

    
January 2010

CBN January 2010

Clinicians' Biosecurity Network Report archive for January 2010.

  1. Anthrax Cases Among Heroin Users in Europe Illustrate Novel Risk (01-22-2010)

    Bacillus anthracis, a ubiquitous but deadly pathogen found in soil, has been primarily an occupational disease, with some exceptions. Recent cases of anthrax, some fatal, in Scotland and Germany highlight a new risk--recreational heroin use.
    Fri, 22 Jan 2010 15:49:15 GMThttp://www.upmc-cbn.org/report_archive/2010/01Jan_2010/cbnreport_01222010.html

  2. Unusual Case of GI Anthrax in New Hampshire Raises Questions (01-08-2010)

    On December 26, 2009, the New Hampshire Department of Health and Human Services announced that a female member of a drumming group was diagnosed with gastrointestinal anthrax, presumably contracted at an event held on December 4.
    Fri, 08 Jan 2010 12:14:40 GMThttp://www.upmc-cbn.org/report_archive/2010/01Jan_2010/cbnreport_01082010.html

  
December 2009

CBN December 2009

Clinicians' Biosecurity Network Report archive for December 2009.

  1. Will the D225G Mutation Herald More Severe Illness in 2009 H1N1 Patients? (12-11-2009)

    To date, the H1N1 influenza A pandemic has been one of the mildest on record. Nonetheless, scientists have been looking for evidence of a mutation that might cause the virus to become more lethal; recently, a mutation was found in a few isolates.
    Wed, 09 Dec 2009 17:42:36 GMThttp://www.upmc-cbn.org/report_archive/2009/12_December_2009/cbnreport_12112009.html

   
October 2009

CBN October 2009

Clinicians' Biosecurity Network Report archive for October 2009.

  1. Antigenic Drift is Not the Sole Factor Driving Evolution of the Influenza Virus (10-30-2009)

    Evolution of seasonal flu A viruses has long been attributed solely to antigenic drift; however, a new study by a team of researchers from the NIH demonstrates that the process is more complex than previously thought.
    Fri, 30 Oct 2009 14:23:13 GMThttp://www.upmc-cbn.org/report_archive/2009/10_October_2009/cbnreport_10302009.html

  2. 2009 H1N1 Influenza Update: Cases, Hospitalizations, and Mortality (10-22-2009)

    This overview of the current status of the 2009 H1N1 influenza pandemic in the U.S. describes the epidemiology, clinical manifestations, and treatment of individuals infected with 2009 H1N1 influenza. Information is current as of October 21, 2009.
    Thu, 22 Oct 2009 20:26:26 GMThttp://www.upmc-cbn.org/report_archive/h1n1/issue_briefs/2009-10-22-H1N1-update_cases.html

  3. Critical Care of H1N1 Influenza A Patients (10-16-2009)

    Reports now emerging from the Southern Hemisphere, and a few other areas, are beginning to paint a clearer picture of both the clinical manifestation of severe H1N1 influenza disease and actual utilization of critical care resources.
    Fri, 16 Oct 2009 13:45:45 GMThttp://www.upmc-cbn.org/report_archive/2009/10_October_2009/cbnreport_10162009.html

  4. Clinical Aspects of H1N1 Influenza A Infection (10-14-2009)

    Several research reports detailing aspects of infection with the pandemic strain of influenza have recently been released. These reports describing clinically relevant aspects of cases are useful for day-to-day management of pandemic influenza.
    Wed, 14 Oct 2009 17:09:24 GMThttp://www.upmc-cbn.org/report_archive/2009/10_October_2009/cbnreport_10142009.html

  5. New IOM Guidance on Crisis Standards of Care for Use in Disaster Situations (10-02-2009)

    On September 24, 2009, the Institute of Medicine's (IOM) Committee on Guidance for Establishing Standards of Care for Use in Disaster Situations released Guidance for Establishing Crisis Standards of Care for Use in Disaster Situations: A Letter Report.
    Fri, 02 Oct 2009 16:38:52 GMThttp://www.upmc-cbn.org/report_archive/2009/10_October_2009/cbnreport_10022009.html

   
September 2009

CBN September 2009

Clinicians' Biosecurity Network Report archive for September 2009.

  1. Single-Dose Vaccination for the 2009 H1N1 Influenza A Virus (09-15-2009)

    Two studies published ahead of print in the New England Journal of Medicine provide evidence that a single dose of vaccine may be sufficient for the 2009 H1N1 influenza A.
    Tue, 15 Sep 2009 19:24:03 GMThttp://www.upmc-cbn.org/report_archive/2009/09_September_2009/cbnreport_09152009.html

  2. H1N1 Dual Infections (09-04-2009)

    As the world is currently in the midst of a WHO stage VI pandemic with the 2009 H1N1 influenza virus, it remains a possibility that this virus could reassort with other flu strains--most notably, the WHO stage III pandemic H5N1 avian influenza virus.
    Fri, 04 Sep 2009 17:35:24 GMThttp://www.upmc-cbn.org/report_archive/2009/09_September_2009/cbnreport_09042009.html

    
August 2009

CBN August 2009

Clinicians' Biosecurity Network Report archive for August 2009.

  1. Zanamivir Resistance in Influenza (08-14-2009)

    Antiviral therapy against influenza always has been plagued by the development of resistance. Unfortunately, as medical mngmnt of flu relies increasingly on antiviral therapy, resistance will become more commonplace, and may render some drugs obsolete.
    Fri, 14 Aug 2009 16:12:42 GMThttp://www.upmc-cbn.org/report_archive/2009/08_August_2009/cbnreport_08142009

   
July 2009

CBN July 2009

Clinicians' Biosecurity Network Report archive for July 2009.

  1. A Novel H3N2 Influenza A Variant Emerges (07-31-2009)

    A new H3N2 variant has emerged that may be poorly matched to the 2009 seasonal flu vaccine. This could pose a risk to the elderly and to those who have been vaccinated against the pandemic strain.
    Fri, 31 Jul 2009 18:41:00 GMThttp://www.upmc-cbn.org/report_archive/2009/07_July_2009/cbnreport_07312009.html

  2. 2009 H1N1 Influenza A: Clinical Details, Antiviral Resistance, and Other Mutations (07-17-09)

    Several scientific papers have been published recently that elucidate both the spectrum of illness caused by the 2009 H1N1 influenza (A) virus and its ability to evade antiviral drugs.
    Fri, 17 Jul 2009 16:39:39 GMThttp://www.upmc-cbn.org/report_archive/2009/07_July_2009/cbnreport_07172009.html

  
June 2009

CBN June 2009

Clinicians' Biosecurity Network Report archive for June 2009.

  1. Healthcare Workers at Risk for H1N1 Infection (06-19-2009)

    There have been cases of the 2009 H1N1 influenza (A) virus among healthcare workers, as detailed in the June 19, 2009 MMWR. It appears that all could have been prevented had standard infection control measures been taken.
    Mon, 06 Jul 2009 15:07:09 GMThttp://www.upmc-cbn.org/report_archive/2009/06_June_2009/cbnreport_06192009.html

  2. H7-subtype Influenza Infections: Pandemic Potential? (06-05-2009)

    However, the pandemic potential of the H7 viruses cannot be overlooked. While they are not nearly as lethal as H5N1, a pandemic need not cause mass lethality to have a significant impact around the globe.
    Fri, 05 Jun 2009 18:48:59 GMThttp://www.upmc-cbn.org/report_archive/2009/06_June_2009/cbnreport_06052009.html

   
May 2009

CBN May 2009

Clinicians' Biosecurity Network Report archive for May 2009.

  1. Hospitals Are Better Prepared for Mass Casualty Disasters (05-08-2009)

    Based on interviews with 133 individuals involved with disaster preparedness in hospitals across the U.S., we found that hospitals are significantly better prepared now than in 2001; much of the improvement is attributable to the HPP.
    Fri, 08 May 2009 16:36:45 GMThttp://www.upmc-cbn.org/report_archive/2009/05_May_2009/cbnreport_05082009.html

  
April 2009

CBN April 2009

Clinicians' Biosecurity Network Report archive for April 2009.

  1. Swine Flu Cases Without Swine Exposure (04-24-2009)

    On 4/21/2009, the CDC described 2 cases of swine flu A (H1N1) infection in Southern CA in April. While both patients recovered uneventfully, the isolated viruses harbor novel genetic characteristics not seen in the U.S. prior to this event.
    Fri, 24 Apr 2009 14:26:22 GMThttp://www.upmc-cbn.org/report_archive/h1n1/04-09_Swine_Flu/cbnreport_SF1_4-24-09_AM.html

  2. Adenovirus 14: An Emerging Threat (04-17-2009)

    The Journal of Infectious Disease has just published 2 papers by teams of researchers describing separate, severe outbreaks of Adenovirus 14 (Ad14), a historically rare serotype of adenovirus that has not been known to cause severe disease.
    Fri, 17 Apr 2009 15:42:36 GMThttp://www.upmc-cbn.org/report_archive/2009/04_April_2009/cbnreport_04172009.html

  3. Oseltamivir Protective Against Influenza-induced Cardiac Events (04-03-2009)

    A new study finds that antiviral therapy can reduce cardiovascular complications following influenza infection in patients with previous cardiac disease.
    Thu, 02 Apr 2009 22:41:56 GMThttp://www.upmc-cbn.org/report_archive/2009/04_April_2009/cbnreport_04032009

   
March 2009

CBN March 2009

Clinicians' Biosecurity Network Report archive for March 2009.

  1. 3rd Generation Smallpox Vaccine LC16m8 Proved Safe and Immunogenic (03-20-2009)

    New JAMA study from Japanese researchers testing LC16m8, tissue-cultured 3rd gen smallpox vaccine. Overall, the vaccine displayed high levels of vaccine take in primary vaccinees and provoked an effective booster response in some revaccinees.
    Fri, 20 Mar 2009 14:31:31 GMThttp://www.upmc-cbn.org/report_archive/2009/03_March_2009/cbnreport_03202009.html

  2. Broad-spectrum Flu Antibodies Characterized (03-06-2009)

    Two teams of researchers recently and simultaneously reported discovery and development of antibodies generated against invariate regions of the influenza virus.
    Fri, 06 Mar 2009 20:10:52 GMThttp://www.upmc-cbn.org/report_archive/2009/03_March_2009/cbnreport_03062009

   
February 2009

CBN Febuary 2009

Clinicians' Biosecurity Network Report archive for February 2009.

  1. Longer Treatment Window for Botulism (02-20-2009)

    Results from a new study published in JID demonstrate the persistence of botulinum toxin in the serum of patients up to 11 days after exposure. The prolonged persistence of toxin allows for admin of anti-toxin as long 12 days after toxin ingestion
    Fri, 20 Feb 2009 18:53:50 GMThttp://www.upmc-cbn.org/report_archive/2009/02_February_2009/cbnreport_02202009.html

  2. Global Avian influenza Panzootic Continues; Some Preparedness Gains Made but Hospitals Remain Vulnerable (02-06-2009)

    Although "bird flu" has not been featured prominently on the evening news of late, the influenza A/H5N1 panzootic continues. And, as has been true since this global outbreak erupted in Thailand and Vietnam, it remains distinctly seasonal in nature.
    Fri, 06 Feb 2009 20:13:05 GMThttp://www.upmc-cbn.org/report_archive/2009/02_February_2009/cbnreport_02062009.html

  
January 2009

CBN January 2009

Clinicians' Biosecurity Network Report archive for January 2009.

  1. Is Airborne Spread of Influenza Possible? (01-22-2009)

    A new study demonstrates that the flu virus is able to remain suspended in the air, thus enabling airborne transmission. This finding suggests the possible need for more stringent infection control measures to forestall spread of flu in hospitals.
    Thu, 22 Jan 2009 21:10:34 GMThttp://www.upmc-cbn.org/report_archive/2009/01_January_2009/cbnreport_01222009.html

  2. Update on Smallpox Vaccine (01-08-2009)

    The 2001 anthrax attacks spurred new vaccine development, and, as a result, there have been several updates to the smallpox vaccine armamentarium, which are reviewed here.
    Fri, 09 Jan 2009 14:42:32 GMThttp://www.upmc-cbn.org/report_archive/2009/01_January_2009/cbnreport_01092009.html

  
December 2008

CBN December 2008

Clinicians' Biosecurity Network Report archive for December 2008.

  1. Update on Personal Protective Equipment (12-19-2008)

    Two recent studies raise questions about best use of PPE and assumptions underlying related current recommendations.
    Fri, 19 Dec 2008 21:43:12 GMThttp://www.upmc-cbn.org/report_archive/2008/12_December_2008/cbnreport_12192008.html

  2. Long-lived Immunity after Smallpox Vaccination (12-05-2008)

    Researchers from NIA have just reported results of a study in which 97% of 209 vaccinated subjects maintained antibody titers for up to 88 years. While promising, these results must be interpreted carefully.
    Fri, 05 Dec 2008 15:05:41 GMThttp://www.upmc-cbn.org/report_archive/2008/12_December_2008/cbnreport_12052008.html

  
November 2008

CBN November 2008

Clinicians' Biosecurity Network Report archive for November 2008.

  1. Modeling Drug Resistant Influenza (11-21-2008)

    In a new mathematical modeling study Brockmann and colleagues report that drug resistant influenza was capable of increasing hospitalization rates by up to 233% in a hypothetical Swiss town of 100,000 inhabitants.
    Mon, 24 Nov 2008 16:44:28 GMThttp://www.upmc-cbn.org/report_archive/2008/11_November_2008/cbnreport_11212008.html

  2. New Arenavirus Identified as Cause of Cluster of Illness and Death in South Africa and Zambia (11-07-2008)

    Through molecular diagnostic techniques, a previously unknown arenavirus has been identified as the etiologic agent responsible for 4 deaths in Africa that occurred in September and October of 2008.
    Fri, 07 Nov 2008 21:12:16 GMThttp://www.upmc-cbn.org/report_archive/2008/11_November_2008/cbnreport_11072008.html

  
October 2008

CBN October 2008

Clinicians' Biosecurity Network Report archive for October 2008.

  1. Rising Staphylococcus aureus Co-infection among Pediatric Influenza Deaths (10-10-2008)

    The results of a study of pediatric flu mortality for 3 flu seasons, by CDC investigators, were published recently. The authors report an increase in the incidence of bacterial co-infection in fatal pediatric flu from 6 to 34 percent in that period.
    Fri, 10 Oct 2008 16:08:11 GMThttp://www.upmc-cbn.org/report_archive/2008/10_October_2008/cbnreport_10092008.html

  
September 2008

CBN September 2008

Clinicians' Biosecurity Network Report archive for September 2008.

  1. Hong Kong Study Finds that Closing Schools May Not Have Helped Slow the Spread of Flu (09-26-2008)

    A new study published in Emerging Infectious Diseases (EID) suggests that Hong Kong�s efforts to close schools for two weeks during the 2008 influenza season may have done little to limit the community-wide spread of influenza.
    Fri, 26 Sep 2008 20:21:39 GMThttp://www.upmc-cbn.org/report_archive/2008/09_September_2008/cbnreport_09262008.html

  2. The Role of Bacterial Pneumonia in Pandemic Influenza (09-12-2008)

    A paper by researchers from NIAID concludes that most deaths during the 1918 flu pandemic appear to have involved bacterial pneumonia rather than purely viral pneumonia. This has important implications for pandemic flu planning now.
    Fri, 12 Sep 2008 21:58:00 GMThttp://www.upmc-cbn.org/report_archive/2008/09_September_2008/cbnreport_09122008.html

 

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Center publications links

2009 H1N1 Influenza Issue Briefs

• H1N1 and MSFWs (11-23-09)

• Vaccine Licensure & Evaluation (11-13-09)

• Surveillance (11-02-09)

• Cases, Hospitalizations, Mortality (10-22-09)

• Complete list of Issue Briefs

Center publications links

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